Estudo do efeito antiinflamatorio do veneno de abelha apis mellifera africanizada em modelos de inflamação aguda e cronica
Suzel A. Frem Bourgerie
TESE
Português
T/UNICAMP B666e
Campinas, SP : [s.n.], 1994.
[77]f. : il.
Orientadores: Carlos Alberto Flores, João Francisco Marques Neto
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
Resumo: No presente trabalho o efeito antiinflamatório do VAA foi estudado em modelos de inflamação aguda (edema de pata induzido por Carragenina, Dextrana e VAA) e crônica (artrite induzida pelo adjuvante completo de Freünd) em ratos Wistar. Observou-se que: 1. O V AA (20,100 e 500 µg, s.c.) inibiu...
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Resumo: No presente trabalho o efeito antiinflamatório do VAA foi estudado em modelos de inflamação aguda (edema de pata induzido por Carragenina, Dextrana e VAA) e crônica (artrite induzida pelo adjuvante completo de Freünd) em ratos Wistar. Observou-se que: 1. O V AA (20,100 e 500 µg, s.c.) inibiu o edema de pata induzido pela carragenina, dextrana e pelo próprio VAA, efeito esse foi dose-dependente; 2. A adrenalectomia suprimiu a inibição do VAA sobre o edema de pata induzido pela carragenina, dextrana e VAA, em pelo menos 80%; 3. O VAAcausou efeito antiinflamatório sobre a artrite induzida por adjuvante completo de Freünd quando administrado profilática e terapeuticamente; 4. A redução da artrite (45%) com o pré-tratamento com VAA (500 µg, s.c., 1.5 dias antes da injeção do adjuvante, 3 doses semanais) foi similar a encontrada com autilização da dexametasona; 5. O estudo anatomo-patológico das articulações com artrite pré-tratada com V AA mostrou acentuada diminuição do infiltrado mononuclear em tecido subcutâneo e periarticular, e praticamente, ausência da formação de granulomas epitelióides, microabcessos, pannus e regeneração óssea; 6. O tratamento da artrite induzida por adjuvante com VAA (500 µg, s.c., diariamente por uma semana, a partir do 17° dia após o adjuvante) reduziu a artrite em cerca de 58% após 3 dias de administração perdendo, porém, a sua eficácia a partir do 4° dia, quando a artrite seguiu o seu curso natural. A análise desses dados nos leva a concluir que o VAA apresenta importante efeito antiinflamatório, dependente em grande parte da glândula adrenal, sendo capaz de alterar o curso do desenvolvimento da artrite induzida pelo adjuvante completo de Freünd, modificando de maneira significativa as alterações histopatológicas dessa patologia
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Abstract: In the present work, the anti-inflammatory action of venom from Africanized bees was studied in a model of acute inflammation (rat paw edema induced by carrageenin, dextran and bee venom itself) and chronic inflammation (arthritis induced by Freünd's complete adjuvant) in Wistar rats. The...
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Abstract: In the present work, the anti-inflammatory action of venom from Africanized bees was studied in a model of acute inflammation (rat paw edema induced by carrageenin, dextran and bee venom itself) and chronic inflammation (arthritis induced by Freünd's complete adjuvant) in Wistar rats. The main conclusions were: 1. Bee venom (20, 00, and 500 µg, s.c.) dose-dependently inhibited the paw edema induced by carrageenin, dextran and the venom itself; 2. Adrenalectomy abolished by more than 80% the venom-induced inhibition of the edema caused by the above agents;
3. Bee venom had an anti-inflammatory action on the arthrits induced by Freünd's complete adjuvant when administered either before or after the latter; 4. The reducion in arthritis (45%) observed following pre-treatment of the animals with bee venom (500 µg, s.c., 3 doses per week for 15 days before the injection of adjuvant), was similar to that observed with dexamethasone; 5. Examination of the arthritic articulations pre-treated with bee venom revealed that there was a marked decrease in the mononuc1ear cell infiltrate into the subcutaneous and periarticular tissue with an almost total absence of epithelioidal granulomas, microabcesses and bone regeneration; 6. Treatment of the adjuvant-induced arthritis with bee venom (500 µg, s.c., daily for one week starting on the seventeenth day after adjuvantadministration) resulted in a decrease of approximately 58% in the arthritis after three days but was ineffective from the fourth day onwards when the arthritis resumed its normal course. The above results suggest that bee venom has important anti-inflammatory activity which is mediated by the adrenal gland. The venom is able to hinder the progress of arthritis induced by Freünd's complete adjuvant and can produced important histopathological alterations Ver menos
3. Bee venom had an anti-inflammatory action on the arthrits induced by Freünd's complete adjuvant when administered either before or after the latter; 4. The reducion in arthritis (45%) observed following pre-treatment of the animals with bee venom (500 µg, s.c., 3 doses per week for 15 days before the injection of adjuvant), was similar to that observed with dexamethasone; 5. Examination of the arthritic articulations pre-treated with bee venom revealed that there was a marked decrease in the mononuc1ear cell infiltrate into the subcutaneous and periarticular tissue with an almost total absence of epithelioidal granulomas, microabcesses and bone regeneration; 6. Treatment of the adjuvant-induced arthritis with bee venom (500 µg, s.c., daily for one week starting on the seventeenth day after adjuvantadministration) resulted in a decrease of approximately 58% in the arthritis after three days but was ineffective from the fourth day onwards when the arthritis resumed its normal course. The above results suggest that bee venom has important anti-inflammatory activity which is mediated by the adrenal gland. The venom is able to hinder the progress of arthritis induced by Freünd's complete adjuvant and can produced important histopathological alterations Ver menos
Estudo do efeito antiinflamatorio do veneno de abelha apis mellifera africanizada em modelos de inflamação aguda e cronica
Suzel A. Frem Bourgerie
Estudo do efeito antiinflamatorio do veneno de abelha apis mellifera africanizada em modelos de inflamação aguda e cronica
Suzel A. Frem Bourgerie
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