Melanoma oral e sinonasal primario = estudo clinicopatologico e imunoistoquimico
Bruno Augusto Benevenuto de Andrade
DISSERTAÇÃO
Português
T/UNICAMP An24m
[Primary oral and sinonasal melanoma]
Piracicaba, SP : [s.n.], 2010.
105 p. : il.
Orientador: Oslei Paes de Almeida
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba
Resumo: O melanoma é um tumor potencialmente agressivo de origem melanocítica. Somente 1% se desenvolve em mucosa oral, correspondendo a 0,5% de todas as malignidades de boca. Apesar do avanço no conhecimento da biologia dos melanomas, o tratamento e prognóstico continuam apresentando limitações,...
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Resumo: O melanoma é um tumor potencialmente agressivo de origem melanocítica. Somente 1% se desenvolve em mucosa oral, correspondendo a 0,5% de todas as malignidades de boca. Apesar do avanço no conhecimento da biologia dos melanomas, o tratamento e prognóstico continuam apresentando limitações, principalmente com relação aos melanomas mucosos de cabeça e pescoço, incluindo nesse grupo os melanomas orais (MO) e sinonasais. O objetivo deste estudo foi analisar as características clínicas, histopatológicas e a expressão de marcadores imunoistoquímicos em 33 casos de MO e sinonasal primário. Treze casos envolviam pacientes do gênero masculino e 20 casos (60,61%) do gênero feminino, com idade média de 57,5 anos, manifestando-se através de lesões nodulares, manchas, áreas de sangramento, ulceração e dormência, especialmente em palato duro (45,45%) e gengiva superior (21,21%). Microscopicamente, quatro casos eram amelanóticos, com predomínio do nível III de invasão (23 casos) e composição celular polimórfica (20 casos) constituída principalmente por células epitelióides e fusiformes. Observou-se em alguns casos necrose, invasão perivascular, perineural, tecido adiposo e infiltrado inflamatório. A análise imunoistoquímica para S-100 e HMB-45 demonstrou positividade em todos os casos, sendo 27 casos (81,82%) e 30 casos (90,91%) positivos em mais de 50% das células tumorais respectivamente. Três casos foram negativos para Melan-A, com 23 casos (69,70%) apresentando positividade maior que 50% das células tumorais. Ki-67 mostrou alta expressão com índice de marcação variando de 15,51% a 63% de positividade, com média de 38,90%. CD68 evidenciou sete casos (50%) com marcação focal, dois casos (14,29%) moderada e cinco casos (35,71%) intensa.
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Abstract: Melanoma is a potentially aggressive tumor of melanocytic origin. Only 1% develop in oral mucosa, accounting for 0,5% of all malignancies of the mouth.
Despite the advances in biological knowledge of melanoma, treatment and prognosis still have limitations, especially in head and neck... Ver mais Abstract: Melanoma is a potentially aggressive tumor of melanocytic origin. Only 1% develop in oral mucosa, accounting for 0,5% of all malignancies of the mouth.
Despite the advances in biological knowledge of melanoma, treatment and prognosis still have limitations, especially in head and neck melanomas, including sinonasal and oral melanomas (OM). The aim of this study was to analyze the clinical, histopathological and expression of immunohistochemical markers in 33 cases of primary sinonasal and OM. Thirteen cases involved male patients and 20 cases (60.61%) were female, the mean age of the patients was 57,5 years, manifesting as nodular lesions, macular and bleeding areas, ulceration and numbness, especially in hard palate (45,45%) and upper gingiva (21,21%). Microscopically, four cases were amelanotic, with predominance of level III of invasion (23 cases) and polymorphous cell composition (20 cases) particularly composed of epithelioid and spindle cells. In some cases were observed necrosis, perivascular, perineural and adipose invasion and inflammatory infiltrate. Immunostaining results for S-100 and HMB-45 showed positivity in all cases, 27 cases (81,82%) and 30 cases (90,91%) with positive rate in more than 50% of tumor cells respectively. Three cases were negative for Melan-A, with 23 cases (69,70%) presented positive results in more than 50% of tumor cells. Ki-67 showed high expression with labeling index ranged from 15,51% to 63% positivity, with an average of 38,90%. CD68 showed seven cases (50%) with focal staining, two cases (14,29%) moderate and five cases (35,71%) intense.
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Despite the advances in biological knowledge of melanoma, treatment and prognosis still have limitations, especially in head and neck... Ver mais Abstract: Melanoma is a potentially aggressive tumor of melanocytic origin. Only 1% develop in oral mucosa, accounting for 0,5% of all malignancies of the mouth.
Despite the advances in biological knowledge of melanoma, treatment and prognosis still have limitations, especially in head and neck melanomas, including sinonasal and oral melanomas (OM). The aim of this study was to analyze the clinical, histopathological and expression of immunohistochemical markers in 33 cases of primary sinonasal and OM. Thirteen cases involved male patients and 20 cases (60.61%) were female, the mean age of the patients was 57,5 years, manifesting as nodular lesions, macular and bleeding areas, ulceration and numbness, especially in hard palate (45,45%) and upper gingiva (21,21%). Microscopically, four cases were amelanotic, with predominance of level III of invasion (23 cases) and polymorphous cell composition (20 cases) particularly composed of epithelioid and spindle cells. In some cases were observed necrosis, perivascular, perineural and adipose invasion and inflammatory infiltrate. Immunostaining results for S-100 and HMB-45 showed positivity in all cases, 27 cases (81,82%) and 30 cases (90,91%) with positive rate in more than 50% of tumor cells respectively. Three cases were negative for Melan-A, with 23 cases (69,70%) presented positive results in more than 50% of tumor cells. Ki-67 showed high expression with labeling index ranged from 15,51% to 63% positivity, with an average of 38,90%. CD68 showed seven cases (50%) with focal staining, two cases (14,29%) moderate and five cases (35,71%) intense.
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Almeida, Oslei Paes de, 1948-
Orientador
Lopes, Márcio Ajudarte, 1967-
Avaliador
Horta, Martinho Campolina Rebello
Avaliador
Graner, Edgard, 1968-
Avaliador
Melanoma oral e sinonasal primario = estudo clinicopatologico e imunoistoquimico
Bruno Augusto Benevenuto de Andrade
Melanoma oral e sinonasal primario = estudo clinicopatologico e imunoistoquimico
Bruno Augusto Benevenuto de Andrade
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