Resumo: Investigamos os efeitos do BAY 41-2272 (5-cyclopropyl-2- [1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-pyrimidin-4-ylamine) sobre a atividade do sistema NADPH (nicotinamide adenine dinucleotide phosphate) oxidase e expressão do gene CYBB que codifica seu componente principal, a proteína gp91-phox , simultaneamente aos níveis intracelulares de GMPc (cyclic guanosine-3', 5'-monophosphate) e AMPc (cyclic adenosine-3', 5'-monophosphate) em células mielomonocíticas humanas THP-1. ... Observação: O resumo, na íntegra, poderá ser visualizado no texto completo da dissertação digital Ver menos

Abstract: We investigated the effects of the BAY 41-2272 (5-cyclopropyl-2- [1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b] pyridin-3-yl]-pyrimidin-4-ylamine) on the NADPH (nicotinamide adenine dinucleotide phosphate) oxidase system, gene expression of gp91-phox, cGMP (cyclic guanosine-3', 5'-monophosphate) levels, and cAMP (cyclic adenosine-3', 5'-monophosphate) levels, in the human myelomonocytic THP-1 cells. ... Note: The complete abstract is available with the full electronic digital dissertation Ver menos