Resumo: O presente trabalho faz uma revisão histopatológica, com várias correlações clinicas, de todos os pacientes com DH vistos de setembro/78 a outubro/88 no Centro Infantil de Investigações Hematológicas Dr. Domingos A. Boldrini (Centro Boldrini), Campinas-SP.Compara estes dados com uma abrangente revisão da literatura. Dos 46 casos vistos no periodo, 37 foram avaliados (9 foram excluidos em virtude de terem feito tratamentos em outros serviços). A idade mediana foi de 7 anos com predominânia do sexo masculino (2:1). Quase metade dos casos, 17/37 (46%), tiveram sintomas sistêmicos tipo "B" (nos paises desenvolvidos a presença de sintomas "B" é mais baixa e varia de 18% a 27%). Metade dos 37 casos foram estádios 111 e IV. Os tratamentos variaram pouco durante este periodo de 10 anos: radioterapia exclusiva (2 casos), esquemas de tratamentos combinados com radioterapia e quimioterapia (em geral MOPP). A partir do segundo semestre de 1986 o Centro Boldrini tratou, as crianças com DH pela orientação do, grupo alemão BFM que preconiza 2 ciclos de quimioterapia (QT) para estádios I e lIA; 4 ciclos de QT para IIB e IIIA e 6 ciclos de QT para IIIE e IV, todos seguidos de radioterapia em campos localizados ¿Observação: O resumo, na íntegra poderá ser visualizado no texto completo da tese digital Ver menos

Abstract: Hodgkin's Disease. (HD) in children is uncommon; represented only 0.08% of alI cancers in Brasil during 1976-80. It has been treated differently of the adult's HD because radiotherapy in children has been associated to frequent late complications. This work anaIysed alI patients seen in Centro de InvestigaçõesHematológicas Dr. Domingos A.Boldrini, in Campinas, Brazil, between September/78and October/88. AlI cases had their slides re-classified pathologically and results were compared with an extensive review of the literature. Nine of the 46 children with HD seen in that period were not considered in the study because they were not totally treated in Centro Boldrini. Among the 37 patients studied, median age was 7 years old with predominance of males (2:1). Forty six percent (17/37) had constitutional symptoms "E" (in developed countries this number is around 18%- 27%). Half of the patients were stage 111 and IV. Treatments changed during the period of study: from exclusive radiotherapy to combined modality with chemotherapy and radiation. Starting in July/86 alI children were conducted under the orientation of the German DAL MulticenterGroup (EFH) with 2 cycIes of chemotherapy (CT) for stages I and lIA; 4 cycles of CT for stages IIE and IIIA and 6 cycles of CT for stages IIIE and IV, always followed by radiotherapy in involved fields ...Note: The complete abstract is available with the full electronic digital thesis or dissertations Ver menos