Orientador : Thales Rocha de Mattos Filho

Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba

Resumo: Ratos albinos machos foram utilizados para investigar os efeitos de antagonista específico de receptores H1 perifericos ,Terfenadina e receptoresH2' Ciroetidina sobre a enzima ?-glutamiltransferase( ?-GT) DO soro destes animais durante a regeneração hepática após hepatectomia parcial. 67...

Resumo: Ratos albinos machos foram utilizados para investigar os efeitos de antagonista específico de receptores H1 perifericos ,Terfenadina e receptoresH2' Ciroetidina sobre a enzima ?-glutamiltransferase( ?-GT) DO soro destes animais durante a regeneração hepática após hepatectomia parcial. 67 ratos divididos em três grupos foram sacrificados respectiva-
mente 6 h, 24 h e 360 h após a tecnica cirurgica. Cada grupo contendo 4 sub-grupos receberam doses de Terfenadina
(2 mg/Kg/dia), Cimetidina (20 ms/Kg/dia), Terfenadina (20mg/Kg/dia)+ Cimetidina (20mg/Kg/dia) e NaCl 0,9;% (Controle),
intraperitonealmente durante o tempo do experimento. Os resultados obtidos sugerem que o antagonista de receptor
H1 periférico- Terfenadina, induziu a atividade da ?-glutamiltransferase no soro de ratos, 360 h após hepatectomia
parcial

Abstract: Adult male albino rats (Wistar strain) were used to investigate the effecte of selective antagonist of only peripheral histamine H1-receptors, Terfenadine and histamine H2-receptors antagonist, Cimetidine on the serum activity of the
enzyme y-glutamiltransferase( ? -GT) during liver...

Abstract: Adult male albino rats (Wistar strain) were used to investigate the effecte of selective antagonist of only peripheral histamine H1-receptors, Terfenadine and histamine H2-receptors antagonist, Cimetidine on the serum activity of the
enzyme y-glutamiltransferase( ? -GT) during liver regeneration after partial hepatectomy. Sixty-seven animals were
randomly divided into three groups and were 'sacrificed respectively, 6 h, 24 h and 360 h postoperatively. Each group was divided into four sub-groups that received ' doses of Terfenadine (2 mg/Kg,/day),Cimetidine (, 20 mg/Kg/day),
Terfenadine (2mg /Kg /day) + Cimetidine (20 mg/Kg/ day) and NaCl 0,9 % (Control), intraperitoneally during the
experimentation. The results obtained suggested that peri - pheral histamine Hl- receptor antagonist - Terfenadine, induced
the 1(-glutamiltransferase serum activity in rats.360 h after partial hepatectomy