Agradecimentos: We dedicate this piece to the memory of Jeffrey N. McKnight (1984–2020). We thank Marco Aurélio Ramirez Vinolo for support and discussion, Karoline Luger, Alexey Soshnev, and Jose C. Reyes for advice on the figures, Vladimir Teif for advice on nucleosome spacing in human cells and Joaquín de Navascués, Vladimir Teif, Charalampos Rallis, and N. Radu Zabet for comments that improved the manuscript. P.D.V.-W.'s work is supported by the University of Essex, a grant from N3CRs (NC/W001047/1), and a FAPESP São Paulo Excellence Chairs special scheme (2019/16113-5); V.D.N. and D.R.d.P. by direct fellowships from FAPESP (2021/00393-9, 2021/00398-0); and N.V.P.A. by a postdoctoral fellowship from FAPESP (2021/05269-4) Ver menos

Abstract: Alternative histone acylations integrate gene expression with cellular metabolic states. Recent measurements of cellular acyl-coenzyme A (acyl-CoA) pools highlight the potential that histone post-translational modifications (PTMs) contribute directly to the regulation of metabolite pools. A metabolite-centric view throws new light onto roles and evolution of histone PTMs Ver menos