Agradecimentos: V.S.P. is thankful the National Council for Scientific and Technological Development (CNPq) (grant 131651/2021-8). A.L.R.C. thanks São Paulo State Research Foundation (FAPESP) for the postdoctoral fellowship (grant #2020/02313–0). L.G.d.l.T. thanks the National Council for Scientific and Technological Development (CNPq) (productivity grant 302212/2019-1). We thank the Coordination for the Improvement of Higher Education Personnel (CAPES) finance code 001. We thank the São Paulo Research Foundation (FAPESP) (Grants #2021/06645-0 and #2021/11564-9) for funding. This research received a grant from São Paulo Research Foundation (FAPESP) (Grants #2021/06645-0 and #2021/11564-9) Ver menos

Abstract: Despite all the progress in the field of liposomes and nanoparticles for applications as drug and gene delivery systems, the specific targeting and immune system escape capabilities of these systems are still limited. Biomimetic nanovesicles emerged as a strategy to overcome these and other limitations associated with synthetic carriers, such as short circulation time, cytotoxicity, and difficulty in crossing biological barriers, since many of the desirable abilities of drug delivery systems are innate characteristics of biological vesicles. Thus, the question arises: would biomimetic nanovesicles be responsible for addressing these advances? It is currently known that biomimetic nanovesicles (BNV) can combine the intrinsic advantages of natural materials with the well-known production methods and controllability of synthetic systems. Besides, the development of the biotechnology and nanotechnology fields has provided a better understanding of the functionalities of biological vesicles and the means for the design and production of biomimetic nanovesicles (BNV). Based on this, this work will focus on tracking the main research on biomimetic nanovesicles (BNV) applied as drug and gene delivery systems, and for vaccines applications. In addition, it will describe the different sources of natural vesicles, the technical perspectives on obtaining them, and the possibility of their hybridization with synthetic liposomes Ver menos