Phenolic composition of peels from different jaboticaba species determined by HPLC-DAD-ESI/MSn and antiproliferative activity in tumor cell lines
Michelly Cristiane Paludo, Silvia Borges Pimentel de Oliveira, Luciana Fontes de Oliveira, Ronan Carlos Colombo, Sergio Gómez-Alonso, Isidro Hermosín-Gutiérrez, Rafaela Prata, Adriano Freitas Lima, José Teixeira Filho, Cristiano Augusto Ballus, Helena Teixeira Godoy
ARTIGO
Inglês
Agradecimentos: The authors thank CNPq – National Coordination of Scientific and Technological Development (process number: 145652/2014-9), Brazil for the financial support of this study and CAPES – Coordination for the Improvement of Higher Education Personnel (CAPES Foundation, Brazil) – Finance...
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Agradecimentos: The authors thank CNPq – National Coordination of Scientific and Technological Development (process number: 145652/2014-9), Brazil for the financial support of this study and CAPES – Coordination for the Improvement of Higher Education Personnel (CAPES Foundation, Brazil) – Finance Code 001 for providing the research laboratory and the PDSE scholarship (process number: 88881.135420/2016-01). We also thank Professor Hernandes Faustino de Carvalho for opening the doors of his laboratory and providing all necessary material for the biological tests
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Abstract: Jaboticaba has been studied extensively, mainly in the context of its phenolic composition. Although there are several varieties, research has been concentrated on Sabará and Paulista due to their greater dispersion. This study aimed to characterize five jaboticaba varieties in terms of...
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Abstract: Jaboticaba has been studied extensively, mainly in the context of its phenolic composition. Although there are several varieties, research has been concentrated on Sabará and Paulista due to their greater dispersion. This study aimed to characterize five jaboticaba varieties in terms of their anthocyanin and nonanthocyanin phenolic compositions and their antiproliferative action on tumor cells of breast and prostate cancer. The most abundant anthocyanins were cyanidin-3-glycoside and delphinidin-3-glycoside. Three myricitin derivatives, 14 quercetin derivatives (including free quercetin), 13 ellagic acid derivatives (including free ellagic acid) and 4 methylellagic acid derivatives were detected. The variety that showed the best antiproliferative action was Pintada (PFP), which was harvested in the 2015 crop. The phenolic compounds showed differences in different crop years however, samples from both years decreased cellular proliferation
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CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ
145652/2014-9
COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES
001
Aberto
Phenolic composition of peels from different jaboticaba species determined by HPLC-DAD-ESI/MSn and antiproliferative activity in tumor cell lines
Michelly Cristiane Paludo, Silvia Borges Pimentel de Oliveira, Luciana Fontes de Oliveira, Ronan Carlos Colombo, Sergio Gómez-Alonso, Isidro Hermosín-Gutiérrez, Rafaela Prata, Adriano Freitas Lima, José Teixeira Filho, Cristiano Augusto Ballus, Helena Teixeira Godoy
Phenolic composition of peels from different jaboticaba species determined by HPLC-DAD-ESI/MSn and antiproliferative activity in tumor cell lines
Michelly Cristiane Paludo, Silvia Borges Pimentel de Oliveira, Luciana Fontes de Oliveira, Ronan Carlos Colombo, Sergio Gómez-Alonso, Isidro Hermosín-Gutiérrez, Rafaela Prata, Adriano Freitas Lima, José Teixeira Filho, Cristiano Augusto Ballus, Helena Teixeira Godoy
Fontes
Current plant biology (Fonte avulsa) |