Agradecimentos: The authors acknowledge the financial support received from São Paulo Research Foundation – FAPESP (2017/23670-2, 2018/18722-6, 2020/15774-5), and CNPq (303063/2018-1, 408285/2018-4, 151005/2019-2). This study was financed in part by the Coordination for the Improvement of Higher Education Personnel – Brasil (CAPES) – Financial code 001 Ver menos

Abstract: Supercritical fluid adsorption (SFA) is a feasible and novel technique that combines the adsorption process with supercritical fluid technology. Nowadays, two techniques originating from SFA are being investigated, supercritical fluid chromatography (SFC) and supercritical fluid impregnation (SFI). SFC aims to achieve a higher concentration of the target compounds or remove undesirable substances through a chromatographic column. SFI aims to impregnate the target compounds in porous materials to protect them against degradation and to promote their controlled release. This work reviews the main applications of SFA in the natural extracts field. First, the principles, technical and practical aspects of supercritical adsorption processes are addressed. Next, a critical review of the literature from the last 15 years on the SFC and SFI processes of natural extracts is presented, emphasizing SFC in semi- and preparative scales and the use of SFI for the development of food packaging and drug delivery of bioactive compounds. Adsorption isotherms are reported for mono-component and multi-component systems. Moreover, the integration between SFA and other high-pressure processes is described and exemplified for natural extracts. Finally, emerging topics and potential opportunities for future innovations are outlined Ver menos