Agradecimentos: Graphical abstract prepared with created with BioRender.com (accessed on 11 May 2022). This research was funded by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brazil (CAPES; Finance Code 001); CNPq (403976/2021-9; 301496/2019-6; 870268/1997-0; 308743/2019-9) and São Paulo Research Foundation (FAPESP; 2015/50333-1; 2018/11069-5; 2015/13320-9, 2019/13465-8; 2019/12244-8; FoRC/CEPID FAPESP Proc. 2013/07914-8). MRMJ acknowledges Red Iberomericana de Alimentos Autoctonos Subutilizados (ALSUB-CYTED, 118RT0543). Graphical abstract prepared with created with BioRender.com (accessed on 28 September 2021) Ver menos

Abstract: Infertility is a growing public health problem. Consumption of antioxidant bioactive food compounds (BFCs) that include micronutrients and non-nutrients has been highlighted as a potential strategy to protect against oxidative and inflammatory damage in the male reproductive system induced by obesity, alcohol, and toxicants and, thus, improve spermatogenesis and the fertility parameters. Paternal consumption of such dietary compounds could not only benefit the fathers but their offspring as well. Studies in the new field of paternal origins of health and disease show that paternal malnutrition can alter sperm epigenome, and this can alter fetal development and program an increased risk of metabolic diseases and breast cancer in adulthood. BFCs, such as ascorbic acid, a-tocopherol, polyunsaturated fatty acids, trace elements, carnitines, N-acetylcysteine, and coenzyme Q10, have been shown to improve male gametogenesis, modulate epigenetics of germ cells, and the epigenetic signature of the offspring, restoring offspring metabolic health induced by stressors during early life. This indicates that, from a father's perspective, preconception is a valuable window of opportunity to start potential nutritional interventions with these BFCs to maximize sperm epigenetic integrity and promote adequate fetal growth and development, thus preventing chronic disease in adulthood Ver menos