Agradecimentos: This review was supported by the University of Illinois at Chicago’s Institute of Biomaterials, Tribocorrosion, and Nanomedicine Lab as well as University of Illinois at Chicago’s College of Dentistry Restorative Dentistry Department. This study was supported by Department of Restorative Dentistry, College of Dentistry, University of Illinois-Chicago, IL, USA. College of Dentistry, Imam Abdulrahman Bin Faisal, Dammam, Saudi Arabia Ver menos

Abstract: Although dental implants have a high success rate, their increased usage has consequently led to increasing complications including peri-implantitis. This review provides a thorough overview of peri-implantitis: definition, risk factors, the role of corrosion in peri-implantitis, treatment, prevention, and future research directions. An online database search was conducted through PubMed, Embase, Scopus, Web of Science and Google Scholar to compile research articles using the keywords: peri-implantitis, dental implant, corrosion, tribocorrosion, titanium, osseointegration, prevention, and treatment and relevant studies were included. Titanium has high biocompatibility due to the ability to form a protective oxide layer. Problems arise as the layer is harmed by corrosion which is influenced by several factors including high concentrations of electrolytes, acidic pH, and/or lipopolysaccharides. Though the relationship between titanium products (ions and particles) and inflammation is still unclear, there is evidence that titanium products can be pro-inflammatory. Current investigations of implant coatings and surface modifications focus mainly on the prevention of corrosion, but no universal usage is found. Future studies should generate a deeper understanding on the specific prevention mechanisms of corrosion as this might reduce peri-implant inflammation Ver menos