MMP-2 and its implications on cardiac function and structure : interplay with inflammation in hypertension
Thaís Ribeiro Vitorino, Alejandro Ferraz do Prado, Stefany Bruno de Assis Cau, Elen Rizzi
ARTIGO
Inglês
Agradecimentos: This study was funded by Fundacao de Amparo à Pesquisa do Estado de São Paulo (FAPESP-Brazil – Grant 2016/13778-8) and Coordenaçao de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Images were created and adapted with BioRender (BioRender.com)
Abstract: Hypertension is one of the leading risk factors for the development of heart failure. Despite being a multifactorial disease, in recent years, preclinical and clinical studies suggest strong evidence of the pivotal role of inflammatory cells and cytokines in the remodeling process and...
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Abstract: Hypertension is one of the leading risk factors for the development of heart failure. Despite being a multifactorial disease, in recent years, preclinical and clinical studies suggest strong evidence of the pivotal role of inflammatory cells and cytokines in the remodeling process and cardiac dysfunction. During the heart remodeling, activation of extracellular matrix metalloproteinases (MMPs) occurs, with MMP-2 being one of the main proteases secreted by cardiomyocytes, fibroblasts, endothelial and inflammatory cells in cardiac tissue. In this review, we will address the process of cardiac remodeling and injury induced by the increase in MMP-2 and the main signaling pathways involving cytokines and inflammatory cells in the process of transcriptional, secretion and activation of MMP-2. In addition, an interaction and coordinated action between MMP-2 and inflammation are explored and significant in maintaining the cardiac cycle. These observations suggest that new therapeutic opportunities targeting MMP-2 could be used to reduce inflammatory biomarkers and reduce cardiac damage in hypertension
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FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
2016/13778-8
COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES
Fechado
Sanchez, Elen Rizzi
Autor
MMP-2 and its implications on cardiac function and structure : interplay with inflammation in hypertension
Thaís Ribeiro Vitorino, Alejandro Ferraz do Prado, Stefany Bruno de Assis Cau, Elen Rizzi
MMP-2 and its implications on cardiac function and structure : interplay with inflammation in hypertension
Thaís Ribeiro Vitorino, Alejandro Ferraz do Prado, Stefany Bruno de Assis Cau, Elen Rizzi
Fontes
Biochemical pharmacology (Fonte avulsa) |