Agradecimentos: This work was supported by the [São Paulo Research Foundation #1] under Grant [number 2020/05539-9]; [Brazilian National Council for Scientific and Technological Development #2] under Grant [number 303509/2019-8]; and [Coordination of Superior Level Staff Improvement #3] under Grant [number 001] Ver menos

Abstract: We propose a machine learning (ML) approach applied to texture features to differentiate primary brain tumors and solitary brain metastasis. Magnetic resonance imaging (MRI) exams of 96 patients were divided into primary tumors (38) and solitary brain metastasis (58). MRI sequences used: diffusion-weighted image (DWI), fluid-attenuated inversion recovery, T1-weighted, T1-weighted SE gadolinium-enhanced, and T2-weighted images. Regions of interest (ROIs) of 10×10 pixels were positioned within the tumors. For each ROI, 40 texture features were extracted and applied to five different ML methods: naive bayes, support vector machine (SVM), stochastic gradient descent, random forest, and tree. The ML methods classified the groups with good differentiation of up to 97.5% of the area under the receiver operator characteristics (ROC) for SVM as the best classifier, especially in the DWI sequence. The method has a reliable classification for the investigation of tumor lesions Ver menos