Development of cassava starch-based films incorporated with phenolic compounds produced by an Amazonian fungus
Lucas de Souza Falcão, Isabella de Lima Oliveira, Raiana Silveira Gurgel, Anne Terezinha Fernandes de Souza, Leilane de Souza Mendonça, Érik Oda Usuda, Thaís Santiago do Amaral, Priscilla Carvalho Veggi, Pedro Henrique Campelo, Marne Carvalho de Vasconcellos, Patrícia Melchionna Albuquerque, Mariana...
Lucas de Souza Falcão, Isabella de Lima Oliveira, Raiana Silveira Gurgel, Anne Terezinha Fernandes de Souza, Leilane de Souza Mendonça, Érik Oda Usuda, Thaís Santiago do Amaral, Priscilla Carvalho Veggi, Pedro Henrique Campelo, Marne Carvalho de Vasconcellos, Patrícia Melchionna Albuquerque, Mariana Agostini de Moraes
ARTIGO
Inglês
Agradecimentos: The authors thank Fundação de Amparo à Pesquisa do Estado do São Paulo (FAPESP, #2020/08212-0 and #2020/07575-2), Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM, #01.02.016301.00287/2021 and #062.00165/2020), Conselho Nacional de Desenvolvimento Científico e Tecnológico...
Ver mais
Agradecimentos: The authors thank Fundação de Amparo à Pesquisa do Estado do São Paulo (FAPESP, #2020/08212-0 and #2020/07575-2), Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM, #01.02.016301.00287/2021 and #062.00165/2020), Conselho Nacional de Desenvolvimento Científico e Tecnológico – CNPq (#165577/2020-7) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES (finance code 001) for their financial support. This research was funded by Fundação de Amparo à Pesquisa do Estado do São Paulo (FAPESP, #2020/08212-0 and #2020/07575-2), Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM, #01.02.016301.00287/2021 and #062.00165/2020), Conselho Nacional de Desenvolvimento Científico e Tecnológico – CNPq (#165577/2020-7) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – CAPES (finance code 001)
Ver menos
Abstract: Drug-release systems have attracted attention over the last few years since they can be used as a substitute for traditional methods of drug delivery. These have the advantage of being directly administered at the treatment site and can maintain the drug at adequate levels for a longer...
Ver mais
Abstract: Drug-release systems have attracted attention over the last few years since they can be used as a substitute for traditional methods of drug delivery. These have the advantage of being directly administered at the treatment site and can maintain the drug at adequate levels for a longer period, thus increasing their efficacy. Starch-based films are interesting candidates for use as matrices for drug release, especially due to starch's non-toxic properties and its biocompatibility. Endophytic fungi are an important source of bioactive molecules, including secondary metabolites such as phenolic compounds with antioxidant activity. In the present study, cassava starch-based films were developed to act as release systems of phenolic compounds with antioxidant activity. The Amazonian endophytic fungus Aspergillus niger MgF2 was cultivated in liquid media, and the fungal extract was obtained by liquid-liquid partition with ethyl acetate. The starch-based films incorporated with the fungal extract were characterized in regards to their physicochemical properties. The release kinetics of the extract from the film and its antioxidant and cytotoxic properties were also evaluated. The films incorporated with the extract presented maximum release after 25 min at 37 °C and pH 6.8. In addition, it was observed that the antioxidant compounds of the fungal extract maintain their activity after being released from the film, and were non-toxic. Therefore, considering the promising physicochemical properties of the extract-incorporated films, and their considerable antioxidant capacity, the films demonstrate great biotechnological potential with diverse applications in the pharmacological and cosmetic industries
Ver menos
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
2020/08212-0; 2020/07575-2
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DO AMAZONAS - FAPEAM
01.02.016301.00287/2021; 062.00165/2020
CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ
165577/2020-7
COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES
Code 001
Fechado
Falcão, Lucas de Souza
Autor
Gurgel, Raiana Silveira
Autor
Development of cassava starch-based films incorporated with phenolic compounds produced by an Amazonian fungus
Lucas de Souza Falcão, Isabella de Lima Oliveira, Raiana Silveira Gurgel, Anne Terezinha Fernandes de Souza, Leilane de Souza Mendonça, Érik Oda Usuda, Thaís Santiago do Amaral, Priscilla Carvalho Veggi, Pedro Henrique Campelo, Marne Carvalho de Vasconcellos, Patrícia Melchionna Albuquerque, Mariana...
Lucas de Souza Falcão, Isabella de Lima Oliveira, Raiana Silveira Gurgel, Anne Terezinha Fernandes de Souza, Leilane de Souza Mendonça, Érik Oda Usuda, Thaís Santiago do Amaral, Priscilla Carvalho Veggi, Pedro Henrique Campelo, Marne Carvalho de Vasconcellos, Patrícia Melchionna Albuquerque, Mariana Agostini de Moraes
Development of cassava starch-based films incorporated with phenolic compounds produced by an Amazonian fungus
Lucas de Souza Falcão, Isabella de Lima Oliveira, Raiana Silveira Gurgel, Anne Terezinha Fernandes de Souza, Leilane de Souza Mendonça, Érik Oda Usuda, Thaís Santiago do Amaral, Priscilla Carvalho Veggi, Pedro Henrique Campelo, Marne Carvalho de Vasconcellos, Patrícia Melchionna Albuquerque, Mariana...
Lucas de Souza Falcão, Isabella de Lima Oliveira, Raiana Silveira Gurgel, Anne Terezinha Fernandes de Souza, Leilane de Souza Mendonça, Érik Oda Usuda, Thaís Santiago do Amaral, Priscilla Carvalho Veggi, Pedro Henrique Campelo, Marne Carvalho de Vasconcellos, Patrícia Melchionna Albuquerque, Mariana Agostini de Moraes
Fontes
International journal of biological macromolecules (Fonte avulsa) |