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The negative inotropic action of canrenone is mediated by L-type calcium current blockade and reduced intracellular calcium transients

The negative inotropic action of canrenone is mediated by L-type calcium current blockade and reduced intracellular calcium transients

A. R. Costa, L. B. Torres, E. Medei, R. A. Ricardo, J. P França, S. Smaili, J. H. M. Nascimento, M. E. M. Oshiro, J. W. M. Bassani, A. T. Ferreira, P. J. F. Tucci

ARTIGO

Inglês

Agradecimentos: The authors are indebted to Dr Rosana Almada Bassani and Dr RobertoMSaraiva for helpful discussions and to Luiz Fernando Rodrigues Junior, Ednei Luiz Antonio and Danilo Bocalini for technical support. This work was supported by grants from the Fundação de Amparo à Pesquisa do Estado... Ver mais
Abstract: Adding spironolactone to standard therapy in heart failure reduces morbidity and mortality, but the underlying mechanisms are not fully understood. We analysed the effect of canrenone, the major active metabolite of spironolactone, on myocardial contractility and intracellular calcium... Ver mais

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP

99/04533-4; 03/14076-7; 05/604578

CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ

300.692/ 80-3; 300632/2005-3

COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES

001

Fechado

The negative inotropic action of canrenone is mediated by L-type calcium current blockade and reduced intracellular calcium transients

A. R. Costa, L. B. Torres, E. Medei, R. A. Ricardo, J. P França, S. Smaili, J. H. M. Nascimento, M. E. M. Oshiro, J. W. M. Bassani, A. T. Ferreira, P. J. F. Tucci

										

The negative inotropic action of canrenone is mediated by L-type calcium current blockade and reduced intracellular calcium transients

A. R. Costa, L. B. Torres, E. Medei, R. A. Ricardo, J. P França, S. Smaili, J. H. M. Nascimento, M. E. M. Oshiro, J. W. M. Bassani, A. T. Ferreira, P. J. F. Tucci

    Fontes

    British journal of pharmacology (Fonte avulsa)