Agradecimentos: We thank Ashland Ltd., Brazil, for kindly donating the Aqualon™ and Plasdone™. We thank HT Nutri for donating the rice bran oil. We thank the Information Technology Center (CTI) Renato Archer for the infrastructure provided. Lima thanks the institutional training program of MCTI/CNPq agencies. We also thank CNPq, Conselho Nacional de Desenvolvimento Científico e Tecnológico—Brasil, and Rafael Felipe Vicentini for his support in elaborating the graphical abstract. This research was funded by study grant CAPES (#88887.802571/2023-00) Ver menos

Abstract: Interest in clean beauty is rising due to minimalism in the formulation of cosmetics, rational use of water, and fewer chemical additives like preservatives, colorants, surfactants, and artificial fragrances. Green ingredients lead to the development of sustainable formulations with advanced performance and are less aggressive to human health and the environment. Currently, the electrospinning technique is used as a simple one-step manufacturing process to produce nanostructured cosmetics under mild temperature conditions. This study focuses on the utilization of rice bran oil (RBO) in the creation of sustainable nanostructured cosmetics for potential cosmetic and well-being applications. Four sustainable formulations were developed to optimize the creation of nanostructured cosmetics using ethyl cellulose and rice bran oil (RBO). Ethanol absolute and polyvinyl pyrrolidone have been chosen to compose the sustainable formulation due to their biocompatibility and biodegradability. We studied four different RBO concentrations regarding morphology, encapsulation efficiency, biodegradability, and cytotoxicity. Nanostructured cosmetics present biomimetic surfaces, high RBO encapsulation ability, low mass loss at simulated physiologic conditions, and non-cytotoxicity. Therefore, the minimalist sustainable formulation does not contain any toxic solvents and incompatible harmful excipients, was nanostructured using a mild manufacturing process, and obtained high RBO entrapment Ver menos