Mortality in sea lions is associated with the introduction of the H5N1 clade 2.3.4.4b virus in Brazil, october 2023 : whole genome sequencing and phylogenetic analysis
Andreina Carvalho Araújo, Andrew Yong Cho, Laura Morais Nascimento Silva, Thais Camilo Corrêa, Gabriela Cristini Souza, Adriana Silva Albuquerque, Eduardo Macagnan, Cristiane K. M. Kolesnikvoas, Rafael Meurer, Jenyffer Vierheller Vieira, Giulia Gaglianone Lemos, André Silva Barreto, Jeferson Luis...
Andreina Carvalho Araújo, Andrew Yong Cho, Laura Morais Nascimento Silva, Thais Camilo Corrêa, Gabriela Cristini Souza, Adriana Silva Albuquerque, Eduardo Macagnan, Cristiane K. M. Kolesnikvoas, Rafael Meurer, Jenyffer Vierheller Vieira, Giulia Gaglianone Lemos, André Silva Barreto, Jeferson Luis Dick, Karina Rejane Groch, Pedro Volkmer Castilho, Deyvid Amgarten, Fernanda Malta, Michael Miller, Erick G. Dorlass, Soledad Palameta, Sun-Hak Lee, Clarice Weis Arns, Edison L. Durigon, João Renato R. Pinho, Dong-Hun Lee, Helena Lage Ferreira
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Agradecimentos: The authors gratefully acknowledge Julia Cristina Benassi Bueno,and Alessandra Greatti for their technical assistance. We thank the support of the Brazilian Post and Telegraph Company (Correios) for transporting our fieldwork supplies and samples. Samples were collected under the...
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Agradecimentos: The authors gratefully acknowledge Julia Cristina Benassi Bueno,and Alessandra Greatti for their technical assistance. We thank the support of the Brazilian Post and Telegraph Company (Correios) for transporting our fieldwork supplies and samples. Samples were collected under the scope of The Santos Basin Beach Monitoring Project (PMP/BS)
conducted by Petrobrás, licensed by the Brazilian Institute of the Environment and Renewable Natural Resources (IBAMA) of the Brazilian Ministry of Environment under ABIO Nº 640/2015. The authors acknowledge all data contributions, i.e, the authors and their originating laboratories responsible for obtaining the specimens, and their submitting laboratories for generating the genetic sequences and metadata and sharing via the GISAID Initiative, on which this research is based. This work is funded by the Ministry of Science, Technology, and Innovation (MCTI-Brazil) and by the National Council for Scientific and Technological Development (CNPq: 403761/2020-4 and 400172/2022-4, 405786/2022-0, and INCT-One: 405786/2022-0). DP, ACA, FF, AG, HLF, and CWA are recipients of the CNPq scholarship. LMNS is the recipient of the CAPES scholarship. We also thank the National Network for Virus Surveillance in Wild Animals (PREVIR Network). A collaborative research project under joint funding from FAPESP (The São Paulo Research Foundation) and NRF (National Research Foundation of Korea). The PMP-BS is funded by PETROBRAS (contract n. 5900.0111281.19.2) Ver menos
conducted by Petrobrás, licensed by the Brazilian Institute of the Environment and Renewable Natural Resources (IBAMA) of the Brazilian Ministry of Environment under ABIO Nº 640/2015. The authors acknowledge all data contributions, i.e, the authors and their originating laboratories responsible for obtaining the specimens, and their submitting laboratories for generating the genetic sequences and metadata and sharing via the GISAID Initiative, on which this research is based. This work is funded by the Ministry of Science, Technology, and Innovation (MCTI-Brazil) and by the National Council for Scientific and Technological Development (CNPq: 403761/2020-4 and 400172/2022-4, 405786/2022-0, and INCT-One: 405786/2022-0). DP, ACA, FF, AG, HLF, and CWA are recipients of the CNPq scholarship. LMNS is the recipient of the CAPES scholarship. We also thank the National Network for Virus Surveillance in Wild Animals (PREVIR Network). A collaborative research project under joint funding from FAPESP (The São Paulo Research Foundation) and NRF (National Research Foundation of Korea). The PMP-BS is funded by PETROBRAS (contract n. 5900.0111281.19.2) Ver menos
Abstract: Clade 2.3.4.4b highly pathogenic avian influenza (HPAI) H5N1 virus was detected in the South American sea lions found dead in Santa Catarina, Brazil, in October 2023. Whole genome sequencing and comparative phylogenetic analysis were conducted to investigate the origin, genetic diversity,...
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Abstract: Clade 2.3.4.4b highly pathogenic avian influenza (HPAI) H5N1 virus was detected in the South American sea lions found dead in Santa Catarina, Brazil, in October 2023. Whole genome sequencing and comparative phylogenetic analysis were conducted to investigate the origin, genetic diversity, and zoonotic potentials of the H5N1 viruses. The H5N1 viruses belonged to the genotype B3.2 of clade 2.3.4.4b H5N1 virus, which was identified in North America and disseminated to South America. They have acquired new amino acid substitutions related to mammalian host affinity. Our study provides insights into the genetic landscape of HPAI H5N1 viruses in Brazil, highlighting the continuous evolutionary processes contributing to their possible adaptation to mammalian hosts
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CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ
403761/2020-4; 400172/2022-4; 405786/2022-0
COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
Aberto
Palameta, Soledad, 1990-
Autor
Mortality in sea lions is associated with the introduction of the H5N1 clade 2.3.4.4b virus in Brazil, october 2023 : whole genome sequencing and phylogenetic analysis
Andreina Carvalho Araújo, Andrew Yong Cho, Laura Morais Nascimento Silva, Thais Camilo Corrêa, Gabriela Cristini Souza, Adriana Silva Albuquerque, Eduardo Macagnan, Cristiane K. M. Kolesnikvoas, Rafael Meurer, Jenyffer Vierheller Vieira, Giulia Gaglianone Lemos, André Silva Barreto, Jeferson Luis...
Andreina Carvalho Araújo, Andrew Yong Cho, Laura Morais Nascimento Silva, Thais Camilo Corrêa, Gabriela Cristini Souza, Adriana Silva Albuquerque, Eduardo Macagnan, Cristiane K. M. Kolesnikvoas, Rafael Meurer, Jenyffer Vierheller Vieira, Giulia Gaglianone Lemos, André Silva Barreto, Jeferson Luis Dick, Karina Rejane Groch, Pedro Volkmer Castilho, Deyvid Amgarten, Fernanda Malta, Michael Miller, Erick G. Dorlass, Soledad Palameta, Sun-Hak Lee, Clarice Weis Arns, Edison L. Durigon, João Renato R. Pinho, Dong-Hun Lee, Helena Lage Ferreira
Mortality in sea lions is associated with the introduction of the H5N1 clade 2.3.4.4b virus in Brazil, october 2023 : whole genome sequencing and phylogenetic analysis
Andreina Carvalho Araújo, Andrew Yong Cho, Laura Morais Nascimento Silva, Thais Camilo Corrêa, Gabriela Cristini Souza, Adriana Silva Albuquerque, Eduardo Macagnan, Cristiane K. M. Kolesnikvoas, Rafael Meurer, Jenyffer Vierheller Vieira, Giulia Gaglianone Lemos, André Silva Barreto, Jeferson Luis...
Andreina Carvalho Araújo, Andrew Yong Cho, Laura Morais Nascimento Silva, Thais Camilo Corrêa, Gabriela Cristini Souza, Adriana Silva Albuquerque, Eduardo Macagnan, Cristiane K. M. Kolesnikvoas, Rafael Meurer, Jenyffer Vierheller Vieira, Giulia Gaglianone Lemos, André Silva Barreto, Jeferson Luis Dick, Karina Rejane Groch, Pedro Volkmer Castilho, Deyvid Amgarten, Fernanda Malta, Michael Miller, Erick G. Dorlass, Soledad Palameta, Sun-Hak Lee, Clarice Weis Arns, Edison L. Durigon, João Renato R. Pinho, Dong-Hun Lee, Helena Lage Ferreira
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