Plasma lipid metabolites as potential biomarkers for identifying individuals at risk of obesity-induced metabolic complications
Paula Emília Nunes Ribeiro Bellot, Erik Sobrinho Braga, Folorunsho Bright Omage, Francisca Leide da Silva Nunes, Severina Carla Vieira Cunha Lima, Clélia Oliveira Lyra, Dirce Maria Lobo Marchioni, Lucia Fatima Campos Pedrosa, Fernando Barbosa, Ljubica Tasic, Karine Cavalcanti Maurício...
Paula Emília Nunes Ribeiro Bellot, Erik Sobrinho Braga, Folorunsho Bright Omage, Francisca Leide da Silva Nunes, Severina Carla Vieira Cunha Lima, Clélia Oliveira Lyra, Dirce Maria Lobo Marchioni, Lucia Fatima Campos Pedrosa, Fernando Barbosa, Ljubica Tasic, Karine Cavalcanti Maurício Sena-Evangelista
ARTIGO
Inglês
Agradecimentos: This study was funded in part by the Coordination of Improvement of Higher Education Personnel (Coordenação de Aperfeiçoamento de Pessoal do Nível Superior—CAPES) (Grant number 001). This work was supported by the National Council for Scientific and Technological Development...
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Agradecimentos: This study was funded in part by the Coordination of Improvement of Higher Education Personnel (Coordenação de Aperfeiçoamento de Pessoal do Nível Superior—CAPES) (Grant number 001). This work was supported by the National Council for Scientific and Technological Development (Conselho Nacional de Desenvolvimento Científico e Tecnológico—CNPq) (Grant numbers: 431053/2016-2 and 405837/20160). We also thank INCTBio and Sao Paulo Research Foundation (Fundação de Amparo à Pesquisa do Estado de São Paulo—FAPESP), Grant numbers #2023/02691-2, #2022/11207-4, #2018/24069-3, #2016/20054-6, and #2014/50867-3
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Abstract: Lipidomics studies have indicated an association between obesity and lipid metabolism dysfunction. This study aimed to evaluate and compare cardiometabolic risk factors, and the lipidomic profile in adults and older people. A cross-sectional study was conducted with 72 individuals, divided...
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Abstract: Lipidomics studies have indicated an association between obesity and lipid metabolism dysfunction. This study aimed to evaluate and compare cardiometabolic risk factors, and the lipidomic profile in adults and older people. A cross-sectional study was conducted with 72 individuals, divided into two sex and age-matched groups: obese (body mass index—BMI?=?30 kg/m2; n?=?36) and non-obese (BMI?<?30 kg/m2; n?=?36). The lipidomic profiles were evaluated in plasma using 1H nuclear magnetic resonance (1H-NMR) spectroscopy. Obese individuals had higher waist circumference (p?<?0.001), visceral adiposity index (p?=?0.029), homeostatic model assessment insulin resistance (HOMA-IR) (p?=?0.010), and triacylglycerols (TAG) levels (p?=?0.018). 1H-NMR analysis identified higher amounts of saturated lipid metabolite fragments, lower levels of unsaturated lipids, and some phosphatidylcholine species in the obese group. Two powerful machine learning (ML) models—k-nearest neighbors (kNN) and XGBoost (XGB) were employed to characterize the lipidomic profile of obese individuals. The results revealed metabolic alterations associated with obesity in the NMR signals. The models achieved high accuracy of 86% and 81%, respectively. The feature importance analysis identified signal at 1.50–1.60 ppm (–CO–CH2–CH2–, Cholesterol and fatty acid in TAG, Phospholipids) to have the highest importance in the two models
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COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES
001
CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ
431053/2016-2; 405837/20160
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
2014/50867-3; 2016/20054-6; 2018/24069-3; 2022/11207-4; 2023/02691-2
Aberto
Tasic, Ljubica, 1970-
Autor
Omage, Folorunsho Bright
Autor
Plasma lipid metabolites as potential biomarkers for identifying individuals at risk of obesity-induced metabolic complications
Paula Emília Nunes Ribeiro Bellot, Erik Sobrinho Braga, Folorunsho Bright Omage, Francisca Leide da Silva Nunes, Severina Carla Vieira Cunha Lima, Clélia Oliveira Lyra, Dirce Maria Lobo Marchioni, Lucia Fatima Campos Pedrosa, Fernando Barbosa, Ljubica Tasic, Karine Cavalcanti Maurício...
Paula Emília Nunes Ribeiro Bellot, Erik Sobrinho Braga, Folorunsho Bright Omage, Francisca Leide da Silva Nunes, Severina Carla Vieira Cunha Lima, Clélia Oliveira Lyra, Dirce Maria Lobo Marchioni, Lucia Fatima Campos Pedrosa, Fernando Barbosa, Ljubica Tasic, Karine Cavalcanti Maurício Sena-Evangelista
Plasma lipid metabolites as potential biomarkers for identifying individuals at risk of obesity-induced metabolic complications
Paula Emília Nunes Ribeiro Bellot, Erik Sobrinho Braga, Folorunsho Bright Omage, Francisca Leide da Silva Nunes, Severina Carla Vieira Cunha Lima, Clélia Oliveira Lyra, Dirce Maria Lobo Marchioni, Lucia Fatima Campos Pedrosa, Fernando Barbosa, Ljubica Tasic, Karine Cavalcanti Maurício...
Paula Emília Nunes Ribeiro Bellot, Erik Sobrinho Braga, Folorunsho Bright Omage, Francisca Leide da Silva Nunes, Severina Carla Vieira Cunha Lima, Clélia Oliveira Lyra, Dirce Maria Lobo Marchioni, Lucia Fatima Campos Pedrosa, Fernando Barbosa, Ljubica Tasic, Karine Cavalcanti Maurício Sena-Evangelista
Fontes
Scientific reports (Fonte avulsa) |