Curcumin encapsulation in functional PLGA nanoparticles : a promising strategy for cancer therapies
Felipe da Silva Feltrin, Tamara Agner, Claudia Sayer, Liliane Maria Ferrareso Lona
ARTIGO
Inglês
Agradecimentos: The authors would like to acknowledge the São Paulo Research Foundation - FAPESP (Grant 2018/12831-8), the Conselho Nacional de Desenvolvimento Científico e Tecnológico – Brazil (CNPq) and the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brazil (CAPES) for financial...
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Agradecimentos: The authors would like to acknowledge the São Paulo Research Foundation - FAPESP (Grant 2018/12831-8), the Conselho Nacional de Desenvolvimento Científico e Tecnológico – Brazil (CNPq) and the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brazil (CAPES) for financial support. The authors also thank the Espaço da Escrita – Pró-Reitoria de Pesquisa – UNICAMP – for the language services provided
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Abstract: Nanoparticles have emerged as promising drug delivery systems for the treatment of several diseases. Novel cancer therapies have exploited these particles as alternative adjuvant therapies to overcome the traditional limitations of radio and chemotherapy. Curcumin is a natural bioactive...
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Abstract: Nanoparticles have emerged as promising drug delivery systems for the treatment of several diseases. Novel cancer therapies have exploited these particles as alternative adjuvant therapies to overcome the traditional limitations of radio and chemotherapy. Curcumin is a natural bioactive compound found in turmeric, that has been reported to show anticancer activity against several types of tumors. Despite some biological limitations regarding its absorption in the human body, curcumin encapsulation in poly(lactic-co-glycolic acid) (PLGA), a non-toxic, biodegradable and biocompatible polymer, represents an effective strategy to deliver a drug to a tumor site. Furthermore, PLGA nanoparticles can be engineered with targeting moieties to reach specific cancer cells, thus enhancing the antitumor effects of curcumin. We herein aim to bring an up-to-date summary of the recently developed strategies for curcumin delivery to different types of cancer cells through encapsulation in PLGA nanoparticles, correlating their effects with those of curcumin on the biological capabilities acquired by cancer cells (cancer hallmarks). We discuss the targeting strategies proposed for advanced curcumin delivery and the respective improvements achieved for each cancer cell analyzed, in addition to exploring the encapsulation techniques employed. The conjugation of correct encapsulation techniques with tumor-oriented targeting design can result in curcumin-loaded PLGA nanoparticles that can successfully integrate the elaborate network of development of alternative cancer treatments along with traditional ones. Finally, the current challenges and future demands to launch these nanoparticles in oncology are comprehensively examined
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FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
2018/12831-8
CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ
COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES
Fechado
Curcumin encapsulation in functional PLGA nanoparticles : a promising strategy for cancer therapies
Felipe da Silva Feltrin, Tamara Agner, Claudia Sayer, Liliane Maria Ferrareso Lona
Curcumin encapsulation in functional PLGA nanoparticles : a promising strategy for cancer therapies
Felipe da Silva Feltrin, Tamara Agner, Claudia Sayer, Liliane Maria Ferrareso Lona
Fontes
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Advances in colloid and interface science Vol. 300 (Feb., 2022), n. art. 102582 |