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Is RK-682 a promiscuous enzyme inhibitor? Synthesis and in vitro evaluation of protein tyrosine phosphatase inhibition of racemic RK-682 and analogues

Is RK-682 a promiscuous enzyme inhibitor? Synthesis and in vitro evaluation of protein tyrosine phosphatase inhibition of racemic RK-682 and analogues

Vânia M.T. Carneiro, Daniela B.B. Trivella, Valéria Scorsato, Viviane L. Beraldo, Mariana P. Dias, Tiago J.P. Sobreira, Ricardo Aparicio, Ronaldo A. Pilli

ARTIGO

Inglês

Agradecimentos: We would like to acknowledge FAPESP (research grants 2009/51602-5, 2010/17544-5, 2011/00457-5 and 2013/07607-8) and Institute of Chemistry/UNICAMP for financial and academic support and the Brazilian National Biosciences Laboratory for the use of the Labo

RK-682 (1) is a natural product known to selectively inhibit protein tyrosine phosphatases (PTPases) and is used commercially as a positive control for phosphatase inhibition in in vitro assays. Protein phosphatases are involved in several human diseases

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP

2009/51602-5; 2010/17544-5; 2011/00457-5; 2013/07607-8

Fechado

Proteína tirosina fosfatase
Inibidores de fosfatases
Inibição enzimática
Artigo original

DOI:

Texto completo:

Is RK-682 a promiscuous enzyme inhibitor? Synthesis and in vitro evaluation of protein tyrosine phosphatase inhibition of racemic RK-682 and analogues

Vânia M.T. Carneiro, Daniela B.B. Trivella, Valéria Scorsato, Viviane L. Beraldo, Mariana P. Dias, Tiago J.P. Sobreira, Ricardo Aparicio, Ronaldo A. Pilli 

										

											
											
										

									

									

										

											

												
Is RK-682 a promiscuous enzyme inhibitor? Synthesis and in vitro evaluation of protein tyrosine phosphatase inhibition of racemic RK-682 and analogues

											

												

														

		

							

					Vânia M.T. Carneiro, Daniela B.B. Trivella, Valéria Scorsato, Viviane L. Beraldo, Mariana P. Dias, Tiago J.P. Sobreira, Ricardo Aparicio, Ronaldo A. Pilli
				

		

	


												

										

										
    
										
    
											
										
    
									
    
								
    
							
    
						
    
					
    
				
    
			
    
		
    
	
    
	

    

	

		
    
			
    
				
    
					
    
								
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European journal of medicinal chemistry (Fonte avulsa)