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Synthesis of 2,5‐disubstituted pyrrolidine alkaloids via A one‐pot cascade using transaminase and reductive aminase biocatalysts

Synthesis of 2,5‐disubstituted pyrrolidine alkaloids via A one‐pot cascade using transaminase and reductive aminase biocatalysts

Bruna Z. Costa, James L. Galman, Iustina Slabu, Scott P. France, Anita J. Marsaioli, Nicholas J. Turner

ARTIGO

Inglês

A multi‐enzymatic cascade process involving transaminases (TAs) and reductive aminases (RedAms) to produce enantiomerically pure 2,5‐disubstituted pyrrolidine alkaloids from their respective 1,4‐diketones is reported. Several TAs were screened and the bes

CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ

307885/2013-5

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP

2014/50249-8; 2014/22967-3; 2015/22513-5

Fechado

Synthesis of 2,5‐disubstituted pyrrolidine alkaloids via A one‐pot cascade using transaminase and reductive aminase biocatalysts

Bruna Z. Costa, James L. Galman, Iustina Slabu, Scott P. France, Anita J. Marsaioli, Nicholas J. Turner

										

Synthesis of 2,5‐disubstituted pyrrolidine alkaloids via A one‐pot cascade using transaminase and reductive aminase biocatalysts

Bruna Z. Costa, James L. Galman, Iustina Slabu, Scott P. France, Anita J. Marsaioli, Nicholas J. Turner

    Fontes

    Chemcatchem (Fonte avulsa)