Agradecimentos: We gratefully acknowledge Dr. Catherine A. Reardon from the Committee on Molecular Metabolism and Nutrition, University of Chicago and from Ben May Department for Cancer Research, University of Chicago, Chicago, IL, USA for the manuscript editing. The authors acknowledge the support of the São Paulo Research Foundation (FAPESP Grants No.
2014/10910-7, no.2015/15626-8, no.2015/26682-6, no.2016/18031-8 and no.2017/05264-7),
National Council for Scientific and Technological Development (CNPq) and FAEPEX. This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001. The authors also acknowledge the website
https://smart.servier.com used to generate the manuscript figures Ver menos

Abstract: Nearly 130 years after the first insights into the existence of mitochondria, new rolesassociated with these organelles continue to emerge. As essential hubs that dictate cell fate, mitochondria integrate cell physiology, signaling pathways and metabolism. Thus, recent research has focused on understanding how these multifaceted functions can be used to improve inflammatory responses and prevent cellular dysfunction. Here, we describe the role of mitochondria on the development and function of immune cells, highlighting metabolic aspects and pointing out some metabolic- independent features of mitochondria that sustain cell function Ver menos