The analgesic effect of dipyrone in peripheral tissue involves two different mechanisms : neuronal K(atp) channel opening and CB(1) receptor activation

The analgesic effect of dipyrone in peripheral tissue involves two different mechanisms : neuronal K(atp) channel opening and CB(1) receptor activation

Gilson Gonçalves dos Santos, Elayne Vieira Dias, Juliana Maia Teixeira, Maria Carolina Pedro Athie, Ivan José Magayewski Bonet, Cláudia Herrera Tambeli, Carlos Amilcar Parada

ARTIGO

Inglês

Agradecimentos: This work was funded by CAPES (Coordination of Improvementof Higher Education Personnel)

Dipyrone (metamizole) is an analgesic pro-drug used to control moderate pain. It is metabolized in two major bioactive metabolites: 4-methylaminoantipyrine (4-MAA) and 4-aminoantipyrine (4-AA). The aim of this study was to investigate the participation of peripheral CB1 and CB2 cannabinoid receptors...

COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES

Fechado

The analgesic effect of dipyrone in peripheral tissue involves two different mechanisms : neuronal K(atp) channel opening and CB(1) receptor activation

Gilson Gonçalves dos Santos, Elayne Vieira Dias, Juliana Maia Teixeira, Maria Carolina Pedro Athie, Ivan José Magayewski Bonet, Cláudia Herrera Tambeli, Carlos Amilcar Parada


										

The analgesic effect of dipyrone in peripheral tissue involves two different mechanisms : neuronal K(atp) channel opening and CB(1) receptor activation

Gilson Gonçalves dos Santos, Elayne Vieira Dias, Juliana Maia Teixeira, Maria Carolina Pedro Athie, Ivan José Magayewski Bonet, Cláudia Herrera Tambeli, Carlos Amilcar Parada

    Fontes

    European journal of pharmacology

    Vol. 741 (Oct., 2014), p. 124-131