Gut bacteria products prevent Aki induced by ischemia-reperfusion
Vinicius Andrade-Oliveira, Mariane T. Amano, Matheus Correa-Costa, Angela Castoldi, Raphael J. F. Felizardo, Danilo C. de Almeida, Enio J. Bassi, Pedro M. Moraes-Vieira, Meire I. Hiyane, Andrea C. D. Rodas, Jean P. S. Peron, Cristhiane F. Aguiar, Marlene A. Reis, Willian R. Ribeiro, Claudete J....
Vinicius Andrade-Oliveira, Mariane T. Amano, Matheus Correa-Costa, Angela Castoldi, Raphael J. F. Felizardo, Danilo C. de Almeida, Enio J. Bassi, Pedro M. Moraes-Vieira, Meire I. Hiyane, Andrea C. D. Rodas, Jean P. S. Peron, Cristhiane F. Aguiar, Marlene A. Reis, Willian R. Ribeiro, Claudete J. Valduga, Rui Curi, Marco Aurelio Ramirez Vinolo, Caroline M. Ferreira, Niels Olsen Saraiva Camara
ARTIGO
Inglês
Short-chain fatty acids (SCFAs) are fermentation end products produced by the intestinal nnicrobiota and have anti-inflammatory and histone deacetylase inhibiting properties. Recently, a dual relationship between the intestine and kidneys has been unraveled. Therefore, we evaluated the role of SCFA...
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Short-chain fatty acids (SCFAs) are fermentation end products produced by the intestinal nnicrobiota and have anti-inflammatory and histone deacetylase inhibiting properties. Recently, a dual relationship between the intestine and kidneys has been unraveled. Therefore, we evaluated the role of SCFA in an AKI model in which the inflammatory process has a detrimental role. We observed that therapy with the three main SCFAs (acetate, propionate, and butyrate) improved renal dysfunction caused by injury. This protection was associated with low levels of local and systemic inflammation, oxidative cellular stress, cell infiltration/activation, and apoptosis. However, it was also associated with an increase in autophagy. Moreover, SCFAs inhibited histone deacetylase activity and modulated the expression levels of enzymes involved in chromatin modification. In vitro analyses showed that SCFAs modulated the inflammatory process, decreasing the maturation of dendritic cells and inhibiting the capacity of these cells to induce CD4(+) and CD8(+) T cell proliferation. Furthermore, SCFAs ameliorated the effects of hypoxia in kidney epithelial cells by improving mitochondria! biogenesis. Notably, mice treated with acetate-producing bacteria also had better outcomes after AKI. Thus, we demonstrate that SCFAs improve organ function and viability after an injury through modulation of the inflammatory process, most likely via epigenetic modification
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CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
2011/01016-2; 12/02270-2
Fechado
DOI: https://doi.org/10.1681/ASN.2014030288
Texto completo: https://jasn.asnjournals.org/content/26/8/1877
Gut bacteria products prevent Aki induced by ischemia-reperfusion
Vinicius Andrade-Oliveira, Mariane T. Amano, Matheus Correa-Costa, Angela Castoldi, Raphael J. F. Felizardo, Danilo C. de Almeida, Enio J. Bassi, Pedro M. Moraes-Vieira, Meire I. Hiyane, Andrea C. D. Rodas, Jean P. S. Peron, Cristhiane F. Aguiar, Marlene A. Reis, Willian R. Ribeiro, Claudete J....
Vinicius Andrade-Oliveira, Mariane T. Amano, Matheus Correa-Costa, Angela Castoldi, Raphael J. F. Felizardo, Danilo C. de Almeida, Enio J. Bassi, Pedro M. Moraes-Vieira, Meire I. Hiyane, Andrea C. D. Rodas, Jean P. S. Peron, Cristhiane F. Aguiar, Marlene A. Reis, Willian R. Ribeiro, Claudete J. Valduga, Rui Curi, Marco Aurelio Ramirez Vinolo, Caroline M. Ferreira, Niels Olsen Saraiva Camara
Gut bacteria products prevent Aki induced by ischemia-reperfusion
Vinicius Andrade-Oliveira, Mariane T. Amano, Matheus Correa-Costa, Angela Castoldi, Raphael J. F. Felizardo, Danilo C. de Almeida, Enio J. Bassi, Pedro M. Moraes-Vieira, Meire I. Hiyane, Andrea C. D. Rodas, Jean P. S. Peron, Cristhiane F. Aguiar, Marlene A. Reis, Willian R. Ribeiro, Claudete J....
Vinicius Andrade-Oliveira, Mariane T. Amano, Matheus Correa-Costa, Angela Castoldi, Raphael J. F. Felizardo, Danilo C. de Almeida, Enio J. Bassi, Pedro M. Moraes-Vieira, Meire I. Hiyane, Andrea C. D. Rodas, Jean P. S. Peron, Cristhiane F. Aguiar, Marlene A. Reis, Willian R. Ribeiro, Claudete J. Valduga, Rui Curi, Marco Aurelio Ramirez Vinolo, Caroline M. Ferreira, Niels Olsen Saraiva Camara
Fontes
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American Society of Nephrology. Journal Vol. 26, no. 8 (Aug., 2015), p. 1877-1888 |