Tumour but not stromal expression of Beta 3 integrin is essential, and is required early, for spontaneous dissemination of bone-metastatic breast cancer

Tumour but not stromal expression of Beta 3 integrin is essential, and is required early, for spontaneous dissemination of bone-metastatic breast cancer

Rachel Zoe Carter, Kelli Cristina Micocci, Anthony Natoli, Richard Paul Redvers, Sophie Paquet-Fifield, Ana Carolina Baptista Moreno Martin, Delphine Denoyer, Xiawei Ling, Soo-Hyun Kim, Rebeka Tomasin, Heloisa Selistre-de-Araujo, Robin Lesley Anderson, Normand Pouliot

ARTIGO

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Agradecimentos: National Health and Medical Research Council of Australia; National Breast Cancer Foundation; National Breast Cancer Foundation

Although many preclinical studies have implicated 3 integrin receptors (v3 and IIb3) in cancer progression, 3 inhibitors have shown only modest efficacy in patients with advanced solid tumours. The limited efficacy of 3 inhibitors in patients could arise from our incomplete understanding of the...

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Tumour but not stromal expression of Beta 3 integrin is essential, and is required early, for spontaneous dissemination of bone-metastatic breast cancer

Rachel Zoe Carter, Kelli Cristina Micocci, Anthony Natoli, Richard Paul Redvers, Sophie Paquet-Fifield, Ana Carolina Baptista Moreno Martin, Delphine Denoyer, Xiawei Ling, Soo-Hyun Kim, Rebeka Tomasin, Heloisa Selistre-de-Araujo, Robin Lesley Anderson, Normand Pouliot


										

Tumour but not stromal expression of Beta 3 integrin is essential, and is required early, for spontaneous dissemination of bone-metastatic breast cancer

Rachel Zoe Carter, Kelli Cristina Micocci, Anthony Natoli, Richard Paul Redvers, Sophie Paquet-Fifield, Ana Carolina Baptista Moreno Martin, Delphine Denoyer, Xiawei Ling, Soo-Hyun Kim, Rebeka Tomasin, Heloisa Selistre-de-Araujo, Robin Lesley Anderson, Normand Pouliot

    Fontes

    Journal of Pathology

    Vol. 235, no. 5 (Apr., 2015), p. 760-772