Poloxamer-based binary hydrogels for delivering tramadol hydrochloride : sol-gel transition studies, dissolution-release kinetics, in vitro toxicity, and pharmacological evaluation

Poloxamer-based binary hydrogels for delivering tramadol hydrochloride : sol-gel transition studies, dissolution-release kinetics, in vitro toxicity, and pharmacological evaluation

Ana Claudia Mendonca dos Santos, Alessandra Cristina Santos Akkari, Iasmin Rosanne Silva Ferreira, Cintia Rodrigues Maruyama, Monica Pascoli, Viviane Aparecida Guilherme, Eneida de Paula, Leonardo Fernandes Fraceto, Renata de Lima, Patricia da Silva Melo, Daniele Ribeiro de Araujo

ARTIGO

Inglês

In this work, poloxamer (PL)-based binary hydrogels, composed of PL 407 and PL 188, were studied with regard to the physicochemical aspects of sol-gel transition and pharmaceutical formulation issues such as dissolution-release profiles. In particular, we evaluated the cytotoxicity, genotoxicity,...

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP

CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ

Fechado

Poloxamer-based binary hydrogels for delivering tramadol hydrochloride : sol-gel transition studies, dissolution-release kinetics, in vitro toxicity, and pharmacological evaluation

Ana Claudia Mendonca dos Santos, Alessandra Cristina Santos Akkari, Iasmin Rosanne Silva Ferreira, Cintia Rodrigues Maruyama, Monica Pascoli, Viviane Aparecida Guilherme, Eneida de Paula, Leonardo Fernandes Fraceto, Renata de Lima, Patricia da Silva Melo, Daniele Ribeiro de Araujo


										

Poloxamer-based binary hydrogels for delivering tramadol hydrochloride : sol-gel transition studies, dissolution-release kinetics, in vitro toxicity, and pharmacological evaluation

Ana Claudia Mendonca dos Santos, Alessandra Cristina Santos Akkari, Iasmin Rosanne Silva Ferreira, Cintia Rodrigues Maruyama, Monica Pascoli, Viviane Aparecida Guilherme, Eneida de Paula, Leonardo Fernandes Fraceto, Renata de Lima, Patricia da Silva Melo, Daniele Ribeiro de Araujo

    Fontes

    International journal of nanomedicine

    Vol. 10 (2015), p. 2391-2401