An Asp49 phospholipase A(2) from snake venom induces cyclooxygenase-2 expression and prostaglandin E-2 production via activation of NF-kappa B, p38MAPK, and PKC in macrophages

An Asp49 phospholipase A(2) from snake venom induces cyclooxygenase-2 expression and prostaglandin E-2 production via activation of NF-kappa B, p38MAPK, and PKC in macrophages

M. A. R. Vinolo, R. Curi, B. Lomonte, V. Moreira, J. M. Gutierrez, C. Teixeira

ARTIGO

Inglês

Agradecimentos: Vicerrectoria de Investigacion (Universidad de Costa Rica)

Phospholipases A(2) (PLA(2)) are key enzymes for production of lipid mediators. We previously demonstrated that a snake venom sPLA(2) named MT-III leads to prostaglandin (PG)E-2 biosynthesis in macrophages by inducing the expression of cyclooxygenase-2 (COX-2). Herein, we explored the molecular...

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP

CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ

Aberto

An Asp49 phospholipase A(2) from snake venom induces cyclooxygenase-2 expression and prostaglandin E-2 production via activation of NF-kappa B, p38MAPK, and PKC in macrophages

M. A. R. Vinolo, R. Curi, B. Lomonte, V. Moreira, J. M. Gutierrez, C. Teixeira


										

An Asp49 phospholipase A(2) from snake venom induces cyclooxygenase-2 expression and prostaglandin E-2 production via activation of NF-kappa B, p38MAPK, and PKC in macrophages

M. A. R. Vinolo, R. Curi, B. Lomonte, V. Moreira, J. M. Gutierrez, C. Teixeira

    Fontes

    Mediators of inflammation

    (2014), n. art. 105879