The brazilian amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids
Jean Paulo de Andrade, Raquel B. Giordani, Laura Torras-Claveria, Natalia Belén Pigni, Strahil Berkov, Mercè Font-Bardia, Teresa Calvet, Eduardo Konrath, Kelly Bueno, Liana G. Sachett, Julie H. Dutilh, Warley de Souza Borges, Francesc Viladomat, Amelia T. Henriques, Jerald J. Nair, José Angelo S....
Jean Paulo de Andrade, Raquel B. Giordani, Laura Torras-Claveria, Natalia Belén Pigni, Strahil Berkov, Mercè Font-Bardia, Teresa Calvet, Eduardo Konrath, Kelly Bueno, Liana G. Sachett, Julie H. Dutilh, Warley de Souza Borges, Francesc Viladomat, Amelia T. Henriques, Jerald J. Nair, José Angelo S. Zuanazzi, Jaume Bastida
ARTIGO
Inglês
Nine Brazilian Amaryllidaceae species were studied for their alkaloid composition and acetylcholinesterase (AChE) inhibitory activity via GC–MS and a modified Ellman assay, respectively. A total of thirty-six alkaloids were identified in these plants, of which Hippeastrum papilio and H. glaucescens...
Nine Brazilian Amaryllidaceae species were studied for their alkaloid composition and acetylcholinesterase (AChE) inhibitory activity via GC–MS and a modified Ellman assay, respectively. A total of thirty-six alkaloids were identified in these plants, of which Hippeastrum papilio and H. glaucescens exhibited the highest galanthamine content and the best IC50 values against AChE. Furthermore, Hippeastrum vittatum and Rhodophiala bifida also showed notable AChE inhibitory effects. X-ray crystallographic data for four galanthamine-type compounds revealed significant differences in the orientation of the N-methyl group, which are shown to be related to AChE inhibition
Fechado
The brazilian amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids
Jean Paulo de Andrade, Raquel B. Giordani, Laura Torras-Claveria, Natalia Belén Pigni, Strahil Berkov, Mercè Font-Bardia, Teresa Calvet, Eduardo Konrath, Kelly Bueno, Liana G. Sachett, Julie H. Dutilh, Warley de Souza Borges, Francesc Viladomat, Amelia T. Henriques, Jerald J. Nair, José Angelo S....
Jean Paulo de Andrade, Raquel B. Giordani, Laura Torras-Claveria, Natalia Belén Pigni, Strahil Berkov, Mercè Font-Bardia, Teresa Calvet, Eduardo Konrath, Kelly Bueno, Liana G. Sachett, Julie H. Dutilh, Warley de Souza Borges, Francesc Viladomat, Amelia T. Henriques, Jerald J. Nair, José Angelo S. Zuanazzi, Jaume Bastida
The brazilian amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids
Jean Paulo de Andrade, Raquel B. Giordani, Laura Torras-Claveria, Natalia Belén Pigni, Strahil Berkov, Mercè Font-Bardia, Teresa Calvet, Eduardo Konrath, Kelly Bueno, Liana G. Sachett, Julie H. Dutilh, Warley de Souza Borges, Francesc Viladomat, Amelia T. Henriques, Jerald J. Nair, José Angelo S....
Jean Paulo de Andrade, Raquel B. Giordani, Laura Torras-Claveria, Natalia Belén Pigni, Strahil Berkov, Mercè Font-Bardia, Teresa Calvet, Eduardo Konrath, Kelly Bueno, Liana G. Sachett, Julie H. Dutilh, Warley de Souza Borges, Francesc Viladomat, Amelia T. Henriques, Jerald J. Nair, José Angelo S. Zuanazzi, Jaume Bastida
Fontes
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Phytochemistry reviews Vol. 15 (Feb., 2016), p. 147-160 |