Indole-3-carbinol attenuates the deleterious gestational effects of bisphenol A exposure on the prostate gland of male F1 rats
J. Z. Brandt, J. A. Anselmo-Franci, T. F. Grassi, L. T. R. Silveira, W. J. Favaro, S. L. Felisbino, L. F. Barbisan, W. R. Scarano
ARTIGO
Inglês
Bisphenol A (BPA) is a chemical that has been investigated for it potential to cause prostate diseases. In this study, pregnant Sprague-Dawley rats were treated with 25 or 250 mu g/kg BPA from gestational day (GD) 10 to GD21 with or without concurrent indole-3-carbinol (I3C) feeding. I3C is a...
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Bisphenol A (BPA) is a chemical that has been investigated for it potential to cause prostate diseases. In this study, pregnant Sprague-Dawley rats were treated with 25 or 250 mu g/kg BPA from gestational day (GD) 10 to GD21 with or without concurrent indole-3-carbinol (I3C) feeding. I3C is a phytochemical, and it affords chemoprotection against many types of neoplasia. Male F1 rats from different litters were euthanized on post-natal day (PND) 21 and PND180. BPA-treated groups showed a significant increase in histopathological lesions, but I3C feeding reversed many of these changes, mainly at PND180. Maternal I3C feeding increased prostate epithelial apoptosis in the BPA-treated groups and across age groups. Furthermore, I3C induced partial normalization of the prostate histoarchitecture. The results pointed to a protective effect of maternal I3C feeding during pregnancy in the BPA-exposed male offspring, thereby indicating reduction in the harmful effects of gestational BPA imprinting on the prostate
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CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ
471646/2011-3
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
2010/17262-0; 2011/01954-2; 2010/14110-4
Fechado
Indole-3-carbinol attenuates the deleterious gestational effects of bisphenol A exposure on the prostate gland of male F1 rats
J. Z. Brandt, J. A. Anselmo-Franci, T. F. Grassi, L. T. R. Silveira, W. J. Favaro, S. L. Felisbino, L. F. Barbisan, W. R. Scarano
Indole-3-carbinol attenuates the deleterious gestational effects of bisphenol A exposure on the prostate gland of male F1 rats
J. Z. Brandt, J. A. Anselmo-Franci, T. F. Grassi, L. T. R. Silveira, W. J. Favaro, S. L. Felisbino, L. F. Barbisan, W. R. Scarano
Fontes
Reproductive toxicology (Fonte avulsa) |