Expression patterns of sirtuin 1-AMPK-autophagy pathway in chronic colitis and inflammation-associated colon neoplasia in IL-10-deficient mice

Expression patterns of sirtuin 1-AMPK-autophagy pathway in chronic colitis and inflammation-associated colon neoplasia in IL-10-deficient mice

Elena Talero, Antonio Alcaide, Javier Ávila-Román, Sofía García-Mauriño, Débora Vendramini-Costa, Virginia Motilva

ARTIGO

Inglês

Agradecimentos: This work was supported by Consejería de Innovación, Ciencia y Empresa-Junta de Andalucía (P09-AGR-5185, Polfanat). We thank “Centro de Investigación, Tecnología e Innovación (CITIUS)” of the University of Seville for providing technical assistance

Interleukin-10-deficient (IL-10 (−/−)) mice spontaneously develop chronic colitis and adenocarcinoma through the dysplasia sequence. Autophagy malfunction is associated to inflammatory bowel disease (IBD) and colorectal cancer (CRC) pathogenesis. Autophagy is regulated by silent information...

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Expression patterns of sirtuin 1-AMPK-autophagy pathway in chronic colitis and inflammation-associated colon neoplasia in IL-10-deficient mice

Elena Talero, Antonio Alcaide, Javier Ávila-Román, Sofía García-Mauriño, Débora Vendramini-Costa, Virginia Motilva


										

Expression patterns of sirtuin 1-AMPK-autophagy pathway in chronic colitis and inflammation-associated colon neoplasia in IL-10-deficient mice

Elena Talero, Antonio Alcaide, Javier Ávila-Román, Sofía García-Mauriño, Débora Vendramini-Costa, Virginia Motilva

    Fontes

    International immunopharmacology

    Vol. 35 (June, 2016), p. 248-256