Synthesis and evaluation of sesquiterpene lactone inhibitors of phospholipase A2 from bothrops jararacussu

Synthesis and evaluation of sesquiterpene lactone inhibitors of phospholipase A2 from bothrops jararacussu

E.S. de Alvarenga, S.A. Silva, L.C.A. Barosa, A.J. Demuner, A.G. Parreira, R.I.M.A. Ribeiro, S. Marcussi, J.M.S. Ferreira, R.R. Resende, P.A. Granjeiro, J.A. Silva, A.M. Soares, S. Marangoni, S.L. da Silva

ARTIGO

Inglês

Several sesquiterpene lactone were synthesized and their inhibitive activities on phospholipase A2 (PLA2) from Bothrops jararacussu venom were evaluated. Compounds Lac01 and Lac02 were efficient against PLA2 edema-inducing, enzymatic and myotoxic activities and it reduces around 85% of myotoxicity...

CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE MINAS GERAIS - FAPEMIG

COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPE

Fechado

Synthesis and evaluation of sesquiterpene lactone inhibitors of phospholipase A2 from bothrops jararacussu

E.S. de Alvarenga, S.A. Silva, L.C.A. Barosa, A.J. Demuner, A.G. Parreira, R.I.M.A. Ribeiro, S. Marcussi, J.M.S. Ferreira, R.R. Resende, P.A. Granjeiro, J.A. Silva, A.M. Soares, S. Marangoni, S.L. da Silva


										

Synthesis and evaluation of sesquiterpene lactone inhibitors of phospholipase A2 from bothrops jararacussu

E.S. de Alvarenga, S.A. Silva, L.C.A. Barosa, A.J. Demuner, A.G. Parreira, R.I.M.A. Ribeiro, S. Marcussi, J.M.S. Ferreira, R.R. Resende, P.A. Granjeiro, J.A. Silva, A.M. Soares, S. Marangoni, S.L. da Silva

    Fontes

    Toxicon: an interdisciplinary journal on the toxins derived from animals, plants and microorganisms

    Vol. 57, no. 1 (Jan., 2011), p. 100-108