Sufentanil–2‐hydroxypropyl‐β‐cyclodextrin inclusion complex for pain treatment : physicochemical, cytotoxicity, and pharmacological evaluation

Sufentanil–2‐hydroxypropyl‐β‐cyclodextrin inclusion complex for pain treatment : physicochemical, cytotoxicity, and pharmacological evaluation

Cristiane Volobuef, Carolina M. Moraes, Lazaro A. S. Nunes, Cintia M. S. Cereda, Fabiano Yokaichiya, Margareth K. K. D. Franco, Angelica F. A. Braga, Eneida De Paula, Giovana Radomille Tofoli, Leonardo F. Fraceto, Daniele R. de Araujo

ARTIGO

Inglês

Sufentanil (SUF) is a synthetic analgesic opioid widely used for the management of acute and chronic pain. This drug was complexed with 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and the physicochemical characterization, in vitro/ex vivo toxicity assays, and pharmacological evaluation were...

CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP

Fechado

Sufentanil–2‐hydroxypropyl‐β‐cyclodextrin inclusion complex for pain treatment : physicochemical, cytotoxicity, and pharmacological evaluation

Cristiane Volobuef, Carolina M. Moraes, Lazaro A. S. Nunes, Cintia M. S. Cereda, Fabiano Yokaichiya, Margareth K. K. D. Franco, Angelica F. A. Braga, Eneida De Paula, Giovana Radomille Tofoli, Leonardo F. Fraceto, Daniele R. de Araujo


										

Sufentanil–2‐hydroxypropyl‐β‐cyclodextrin inclusion complex for pain treatment : physicochemical, cytotoxicity, and pharmacological evaluation

Cristiane Volobuef, Carolina M. Moraes, Lazaro A. S. Nunes, Cintia M. S. Cereda, Fabiano Yokaichiya, Margareth K. K. D. Franco, Angelica F. A. Braga, Eneida De Paula, Giovana Radomille Tofoli, Leonardo F. Fraceto, Daniele R. de Araujo

    Fontes

    Journal of pharmaceutical sciences

    Vol. 101, no. 10 (Oct., 2012), p. 3698-3707