Thrombomodulin is required for the antithrombotic activity of thrombin mutant W215A/E217A in a mouse model of arterial thrombosis

Thrombomodulin is required for the antithrombotic activity of thrombin mutant W215A/E217A in a mouse model of arterial thrombosis

Cristina P. Vicente, Hartmut Weiler, Enrico Di Cera, Douglas M. Tollefsen

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Introduction: The thrombin mutant W215A/E217A (WE thrombin) has greatly reduced procoagulant activity, but it activates protein C in the presence of thrombomodulin and inhibits binding of platelet glycoprotein Ib to von Willebrand factor and collagen under flow conditions. Both...

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Thrombomodulin is required for the antithrombotic activity of thrombin mutant W215A/E217A in a mouse model of arterial thrombosis

Cristina P. Vicente, Hartmut Weiler, Enrico Di Cera, Douglas M. Tollefsen


										

Thrombomodulin is required for the antithrombotic activity of thrombin mutant W215A/E217A in a mouse model of arterial thrombosis

Cristina P. Vicente, Hartmut Weiler, Enrico Di Cera, Douglas M. Tollefsen

    Fontes

    Thrombosis research

    Vol. 130, no. 4 (Oct., 2012), p. 646-648