Improvement of tetracaine antinociceptive effect by inclusion in cyclodextrins

Improvement of tetracaine antinociceptive effect by inclusion in cyclodextrins

Roberta Aline Franco de Lima, Marcelo Bispo de Jesus, Cintia Maria Saia Cereda, Giovana Radomille Tofoli, Luis Fernando Cabeca, Irineu Mazzaro, Leonardo Fernandes Fraceto, Eneida de Paula

ARTIGO

Inglês

Local anesthetics (LA) are among the most important pharmacological compounds used to attenuate or eliminate pain. However, systemic toxicity is still a limitation for LA application, especially for ester-type drugs, such as tetracaine (TTC) that presents poor chemical stability (due to hydrolysis...

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP

CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ

Fechado

Improvement of tetracaine antinociceptive effect by inclusion in cyclodextrins

Roberta Aline Franco de Lima, Marcelo Bispo de Jesus, Cintia Maria Saia Cereda, Giovana Radomille Tofoli, Luis Fernando Cabeca, Irineu Mazzaro, Leonardo Fernandes Fraceto, Eneida de Paula


										

Improvement of tetracaine antinociceptive effect by inclusion in cyclodextrins

Roberta Aline Franco de Lima, Marcelo Bispo de Jesus, Cintia Maria Saia Cereda, Giovana Radomille Tofoli, Luis Fernando Cabeca, Irineu Mazzaro, Leonardo Fernandes Fraceto, Eneida de Paula

    Fontes

    Journal of drug targeting

    Vol. 20, no. 1 (Jan., 2012), p. 85-96