Cavities determine the pressure unfolding of proteins

Cavities determine the pressure unfolding of proteins

Julien Roche, Jose A. Caro, Douglas R. Norberto, Philippe Barthe, Christian Roumestand, Jamie L. Schlessman, Angel E. Garcia, Bertrand Garcia-Moreno E, Catherine A. Royer

ARTIGO

Inglês

It has been known for nearly 100 years that pressure unfolds proteins, yet the physical basis of this effect is not understood. Unfolding by pressure implies that the molar volume of the unfolded state of a protein is smaller than that of the folded state. This decrease in volume has been proposed...

COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES

Fechado

Cavities determine the pressure unfolding of proteins

Julien Roche, Jose A. Caro, Douglas R. Norberto, Philippe Barthe, Christian Roumestand, Jamie L. Schlessman, Angel E. Garcia, Bertrand Garcia-Moreno E, Catherine A. Royer


										

Cavities determine the pressure unfolding of proteins

Julien Roche, Jose A. Caro, Douglas R. Norberto, Philippe Barthe, Christian Roumestand, Jamie L. Schlessman, Angel E. Garcia, Bertrand Garcia-Moreno E, Catherine A. Royer

    Fontes

    Proceedings of the National Academy of Sciences of the United States of America

    Vol. 109, no. 18 (May, 2012), p. 6945-6950