The cytokines interleukin (IL)‐1β and tumor necrosis factor (TNF)‐α induce β‐cell death in type 1 diabetes via NF‐κB activation. IL‐1β induces a more marked NF‐κB activation than TNF‐α, with higher expression of genes involved in β‐cell dysfunction and death. We show here a differential usage of the...

The cytokines interleukin (IL)‐1β and tumor necrosis factor (TNF)‐α induce β‐cell death in type 1 diabetes via NF‐κB activation. IL‐1β induces a more marked NF‐κB activation than TNF‐α, with higher expression of genes involved in β‐cell dysfunction and death. We show here a differential usage of the IKK complex by IL‐1β and TNF‐α in β‐cells. While TNF‐α uses IKK complexes containing both IKKα and IKKβ, IL‐1β induces complexes with IKKα only; this effect is achieved by induction of IKKβ degradation via the proteasome. Both IKKγ and activation of the TRAF6‐TAK1‐JNK pathway are involved in IL‐1β‐induced IKKβ degradation

COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP

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