Differential usage of NF‐κB activating signals by IL‐1β and TNF‐α in pancreatic beta cells

Differential usage of NF‐κB activating signals by IL‐1β and TNF‐α in pancreatic beta cells

F. Ortis, M. Miani, M. L. Colli, D. A. Cunha, E. N. Gurzov, F. Allagnat, A. Chariot, D. L. Eizirik

ARTIGO

Inglês

The cytokines interleukin (IL)‐1β and tumor necrosis factor (TNF)‐α induce β‐cell death in type 1 diabetes via NF‐κB activation. IL‐1β induces a more marked NF‐κB activation than TNF‐α, with higher expression of genes involved in β‐cell dysfunction and death. We show here a differential usage of the...

COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP

Fechado

Differential usage of NF‐κB activating signals by IL‐1β and TNF‐α in pancreatic beta cells

F. Ortis, M. Miani, M. L. Colli, D. A. Cunha, E. N. Gurzov, F. Allagnat, A. Chariot, D. L. Eizirik


										

Differential usage of NF‐κB activating signals by IL‐1β and TNF‐α in pancreatic beta cells

F. Ortis, M. Miani, M. L. Colli, D. A. Cunha, E. N. Gurzov, F. Allagnat, A. Chariot, D. L. Eizirik

    Fontes

    FEBS letters

    Vol. 586, no. 7 (Apr., 2012), p. 984-989