Two new hydronaphthoquinones from Sinningia aggregata (Gesneriaceae) and cytotoxic activity of aggregatin D
Maria Helena Verdan, Lauro Mera de Souza, João Ernesto de Carvalho, Débora B. Vendramini Costa, Marcos José Salvador, Andersson Barison, Maria Élida Alves Stefanello
ARTIGO
Inglês
Agradecimentos: The authors are grateful to CNPq and FAPESP for financial support, and to Clarisse B. Poliquesi(Museu Botânico Municipal de Curitiba) for plant identification
Two new hydronaphthoquinones, aggregatins E and F (1 and 2, resp.) were isolated from the tubers of Sinningia aggregata (KER-GAWL.) WIEHLER (Gesneriaceae), along with twelve known compounds aggregatin D (3), tectoquinone (4), 1-hydroxy-2-methylanthraquinone (5), icosyl ferulate (6), pustuline (7),...
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Two new hydronaphthoquinones, aggregatins E and F (1 and 2, resp.) were isolated from the tubers of Sinningia aggregata (KER-GAWL.) WIEHLER (Gesneriaceae), along with twelve known compounds aggregatin D (3), tectoquinone (4), 1-hydroxy-2-methylanthraquinone (5), icosyl ferulate (6), pustuline (7), 1,6-dihydroxy-2-methylanthranquinone (8), 6-hydroxy-2-methylanthraquinone (9), 7-hydroxy-2-methylanthraquinone (10), tyrosol (11), halleridone (12), calceolarioside B (13), and cornoside (14). All compounds were identified by analysis of spectroscopic and spectrometric data. Compounds 3, 4, and 10 had already been reported in this species. Compounds 2 and 3 were evaluated against several tumor cell lines, but only 3 exhibited activities against UACC-62, 786-0 and OVCAR-3 cell lines, with IC50 values of 12.3, 12.8 and 0.3 μg/ml, respectively, without toxic effects on non-cancer cell line HaCat (human keratinocyte)
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CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
fechado
Two new hydronaphthoquinones from Sinningia aggregata (Gesneriaceae) and cytotoxic activity of aggregatin D
Maria Helena Verdan, Lauro Mera de Souza, João Ernesto de Carvalho, Débora B. Vendramini Costa, Marcos José Salvador, Andersson Barison, Maria Élida Alves Stefanello
Two new hydronaphthoquinones from Sinningia aggregata (Gesneriaceae) and cytotoxic activity of aggregatin D
Maria Helena Verdan, Lauro Mera de Souza, João Ernesto de Carvalho, Débora B. Vendramini Costa, Marcos José Salvador, Andersson Barison, Maria Élida Alves Stefanello
Fontes
Chemistry and biodiversity (Fonte avulsa) |