Development of a recombinant fusion protein based on the dynein light chain LC8 for non-viral gene delivery

Development of a recombinant fusion protein based on the dynein light chain LC8 for non-viral gene delivery

Marcelo A. S. Toledo, Richard Janissen, Marianna T. P. Favaro, Mônica A. Cotta, Gabriel A. Monteiro, Duarte Miguel F. Prazeres, Anete P. Souza, Adriano R. Azzoni

ARTIGO

Inglês

Agradecimentos: The authors gratefully acknowledge the financial support of the Fundação de Amparo à Pesquisa do Estado de São Paulo – FAPESP (São Paulo, Brazil). We also thank the Laboratório de Espectroscopia e Calorimetria (LEC), Laboratório Nacional de Biociências – LNBio (Campinas, Brazil), for...

Abstract: The low efficiency of gene transfer is a recurrent problem in DNA vaccine development and gene therapy studies using non-viral vectors such as plasmid DNA (pDNA). This is mainly due to the fact that during their traffic to the target cell's nuclei, plasmid vectors must overcome a series of...

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP

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Development of a recombinant fusion protein based on the dynein light chain LC8 for non-viral gene delivery

Marcelo A. S. Toledo, Richard Janissen, Marianna T. P. Favaro, Mônica A. Cotta, Gabriel A. Monteiro, Duarte Miguel F. Prazeres, Anete P. Souza, Adriano R. Azzoni


										

Development of a recombinant fusion protein based on the dynein light chain LC8 for non-viral gene delivery

Marcelo A. S. Toledo, Richard Janissen, Marianna T. P. Favaro, Mônica A. Cotta, Gabriel A. Monteiro, Duarte Miguel F. Prazeres, Anete P. Souza, Adriano R. Azzoni

    Fontes

    Journal of controlled release

    Vol. 159, n. 2 (Apr., 2012), p. 222-231