Photothermia and activated drug release of natural cell membrane coated plasmonic gold nanorods and β-lapachone
ARTIGO
Inglês
Plasmonic gold nanoparticles present extraordinary potential for near-infrared photothermal and triggered-therapeutic release treatments of solid tumors. In this study, we create a multifunctional nanocarrier in which PEG-coated gold nanorods are grouped into natural cell membrane vesicles (CM) from...
Plasmonic gold nanoparticles present extraordinary potential for near-infrared photothermal and triggered-therapeutic release treatments of solid tumors. In this study, we create a multifunctional nanocarrier in which PEG-coated gold nanorods are grouped into natural cell membrane vesicles (CM) from lung cancer (A549) cells and loaded with β-lapachone (CM-β-Lap-PEG-AuNRs). β-Lapachone (β-Lap) is an anticancer agent activated by the enzyme NADP(H):quinine oxidoreductase (NQO1), commonly found at higher levels in cancer cells. The irradiation with near-infrared (NIR) laser leads to disruption of the vesicles and release of the PEG-AuNRs and β-Lap. The system presents an enhanced in vitro cytotoxicity against A549 cancer cells, which can be attributed to the specific cytotoxicity of β-Lap combined with heat generated by laser irradiation of the AuNRs. In agreement, in vivo treatment with CM-β-Lap-PEG-AuNRs and irradiation shows a histopathological recovery from nonmuscle invasive bladder cancer of most of the animals with only one cycle of application and irradiation. Such multifunctional platform is a promissing candidate for improved activated drug release and phototherapy
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
2012/11166-4
Fechado
DOI: https://doi.org/10.1021/acsabm.8b00603
Texto completo: https://pubs.acs.org/doi/10.1021/acsabm.8b00603
Photothermia and activated drug release of natural cell membrane coated plasmonic gold nanorods and β-lapachone
Photothermia and activated drug release of natural cell membrane coated plasmonic gold nanorods and β-lapachone
Fontes
ACS applied bio materials Vol. 2, no. 2 (2019), p. 728-736 |