Agradecimentos: The authors are grateful to Luiz Roberto Falleiros Junior for technical assistance, as well as colleagues at the Laboratory of Microscopy and Microanalysis. This paper forms part of the M.Sc. thesis presented by Juliana S. Maldarine to the Institute of Biology, UNICAMP, in partial...

Agradecimentos: The authors are grateful to Luiz Roberto Falleiros Junior for technical assistance, as well as colleagues at the Laboratory of Microscopy and Microanalysis. This paper forms part of the M.Sc. thesis presented by Juliana S. Maldarine to the Institute of Biology, UNICAMP, in partial fulfilment of the requirements for an M.Sc. degree. This study was funded by grants from FAPESP (2013/15939-0 and 2016/16509-8) and CNPq (National Council of Scientific and Technological Development; 305840/2015-0 and 442630/ 2014-0)

Finasteride is a drug that is widely used in the treatment of benign prostatic hyperplasia, hair loss and even as a chemotherapeutic agent in the treatment of prostatic adenocarcinoma. However, its use is known to cause several side effects in adults and it can also cause changes in the embryonic...

Finasteride is a drug that is widely used in the treatment of benign prostatic hyperplasia, hair loss and even as a chemotherapeutic agent in the treatment of prostatic adenocarcinoma. However, its use is known to cause several side effects in adults and it can also cause changes in the embryonic development of the male prostate, which is a cause for concern given the possibility of the accumulation of finasteride in the environment. Nevertheless, no studies have investigated the effects of finasteride on the development of the prostate in females, which occurs in several species of mammals. To evaluate the effects of intrauterine exposure to finasteride (500 mg kg 1 day 1 ) on postnatal prostate development in the Mongolian gerbil in the present study, we used immunohistochemistry, immunofluorescence, serological analysis and three-dimensional reconstruction techniques. Differences were observed in the effects of finasteride on periductal smooth muscle and cell proliferation between the sexes, as well as intersex differences in the presence of the androgen receptor, which was elevated in males, and the oestrogen receptor ERa, which was increased in females. Together, the data indicate that the female prostate has its own hormone dynamics and that there are sex-specific differences in the way in which the female prostate reacts to prenatal exposure to finasteride

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP

2013/15939-0; 2016/16509-8

CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ

305840/2015-0; 442630/ 2014-0

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