Beneficial effects of soluble guanylyl cyclase stimulation and activation in sickle cell disease are amplified by hydroxyurea : in vitro and in vivo studies

Beneficial effects of soluble guanylyl cyclase stimulation and activation in sickle cell disease are amplified by hydroxyurea : in vitro and in vivo studies

Jr. Ferreira W. A., H. Chweih, C. Lanaro, C. B. Almeida, P. L. Brito, E. M. F. Gotardo, L. Torres, I Miguel L., C. F. Franco-Penteado, F. C. Leonardo, F. Garcia, S. T. O. Saad, P. S. Frenette, D. Brockschnieder, F. F. Costa, J. P. Stasch, P. Sandner, N. Conran

ARTIGO

Inglês

The complex pathophysiology of sickle cell anemia (SCA) involves intravascular hemolytic processes and recurrent vaso-occlusion, driven by chronic vascular inflammation, which result in the disease's severe clinical complications, including recurrent painful vaso-occlusive episodes. Hydroxyurea, the...

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Fechado

Beneficial effects of soluble guanylyl cyclase stimulation and activation in sickle cell disease are amplified by hydroxyurea : in vitro and in vivo studies

Jr. Ferreira W. A., H. Chweih, C. Lanaro, C. B. Almeida, P. L. Brito, E. M. F. Gotardo, L. Torres, I Miguel L., C. F. Franco-Penteado, F. C. Leonardo, F. Garcia, S. T. O. Saad, P. S. Frenette, D. Brockschnieder, F. F. Costa, J. P. Stasch, P. Sandner, N. Conran


										

Beneficial effects of soluble guanylyl cyclase stimulation and activation in sickle cell disease are amplified by hydroxyurea : in vitro and in vivo studies

Jr. Ferreira W. A., H. Chweih, C. Lanaro, C. B. Almeida, P. L. Brito, E. M. F. Gotardo, L. Torres, I Miguel L., C. F. Franco-Penteado, F. C. Leonardo, F. Garcia, S. T. O. Saad, P. S. Frenette, D. Brockschnieder, F. F. Costa, J. P. Stasch, P. Sandner, N. Conran

    Fontes

    Journal of pharmacology and experimental therapeutics

    Vol. 374, no. 3 (Sep., 2020), p. 469-478