Optimization of in situ derivatization SPME by experimental design for GC‐MS multi‐residue analysis of pharmaceutical drugs in wastewater
Paulo Clairmont Feitosa de Lima Gomes, Juliana Yamashita Barletta, Carlos Eduardo Domingues Nazario, Álvaro José Santos-Neto, Marya Anne Von Wolff, Cassiana Maria Reganhan Coneglian, Gisela Aragão Umbuzeiro, Fernando Mauro Lancas
ARTIGO
Inglês
Agradecimentos: The authors are grateful to CAPES, CNPq, and Fapesp (Project No. 07/03844-4 and 05/59360-0) for financial support, and Alexandre Cruz for the instrumental support during the project execution
Abstract: This paper presents the development of a procedure, which enables the analysis of nine pharmaceutical drugs in wastewater using gas chromatography-mass spectrometry (GC-MS) associated with solid-phase microextraction (SPME) for the sample preparation. Experimental design was applied to...
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Abstract: This paper presents the development of a procedure, which enables the analysis of nine pharmaceutical drugs in wastewater using gas chromatography-mass spectrometry (GC-MS) associated with solid-phase microextraction (SPME) for the sample preparation. Experimental design was applied to optimize the in situ derivatization and the SPME extraction conditions. Ethyl chloroformate (ECF) was employed as derivatizing agent and polydimethylsiloxane-divinylbenzene (PDMS-DVB) as the SPME fiber coating. A fractional factorial design was used to evaluate the main factors for the in situ derivatization and SPME extraction. Thereafter, a Doehlert matrix design was applied to find out the best experimental conditions. The method presented a linear range from 0.5 to 10?µg/L, and the intraday and interday precision were lower than 16%. Applicability of the method was verified from real influent and effluent samples of a wastewater treatment plant, as well as from samples of an industry wastewater and a river
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FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
2005/59360-0; 2007/03844-4
CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ
COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES
Fechado
Optimization of in situ derivatization SPME by experimental design for GC‐MS multi‐residue analysis of pharmaceutical drugs in wastewater
Paulo Clairmont Feitosa de Lima Gomes, Juliana Yamashita Barletta, Carlos Eduardo Domingues Nazario, Álvaro José Santos-Neto, Marya Anne Von Wolff, Cassiana Maria Reganhan Coneglian, Gisela Aragão Umbuzeiro, Fernando Mauro Lancas
Optimization of in situ derivatization SPME by experimental design for GC‐MS multi‐residue analysis of pharmaceutical drugs in wastewater
Paulo Clairmont Feitosa de Lima Gomes, Juliana Yamashita Barletta, Carlos Eduardo Domingues Nazario, Álvaro José Santos-Neto, Marya Anne Von Wolff, Cassiana Maria Reganhan Coneglian, Gisela Aragão Umbuzeiro, Fernando Mauro Lancas
Fontes
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Journal of separation science v. 34, n. 4, p. 436-445, Feb. 2011 |