Agradecimentos: This study was supported by the São Paulo Research Foundation - FAPESP (grants 2008/10449-7 and 2014/50945-4), Brazilian National Council for Scientific and Technological Development - CNPq (465571/2014-0) and by the Coordination for the Improvement of Higher Education Personnel -...

Agradecimentos: This study was supported by the São Paulo Research Foundation - FAPESP (grants 2008/10449-7 and 2014/50945-4), Brazilian National Council for Scientific and Technological Development - CNPq (465571/2014-0) and by the Coordination for the Improvement of Higher Education Personnel - CAPES. The authors are grateful to Paulo Cesar Georgete for technical assistance

Abstract: Color Index (C.I.) Disperse Blue 291 (DB291) is an azo dye used by the textile industry. After yarn dyeing, wastewater containing the dye, released into the aquatic environment, may pollute drinking water sources. We investigated the mutagenicity and genotoxicity of DB291 in male Swiss...

Abstract: Color Index (C.I.) Disperse Blue 291 (DB291) is an azo dye used by the textile industry. After yarn dyeing, wastewater containing the dye, released into the aquatic environment, may pollute drinking water sources. We investigated the mutagenicity and genotoxicity of DB291 in male Swiss mice, following oral administration. Micronucleated cells, primary DNA damage (comet assay) in blood, liver, and kidney cells, and BAX, BCL2, SMAD4 and TNFA gene expression in leukocytes were evaluated. An increased frequency of micronucleated polychromatic erythrocytes (MNPCEs) was observed in animals treated with 50 mg/kg bw; no other genetic alteration was detected. Neither primary DNA damage nor changes in gene expression were observed

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP

2008/10449-7; 2014/50945-4

CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ

465571/2014-0

COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES

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