Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer

Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer

Giorgia Zadra, Caroline F. Ribeiro, Paolo Chetta, Yeung Ho, Stefano Cacciatore, Xueliang Gao, Sudeepa Syamala, Clyde Bango, Cornelia Photopoulos, Ying Huang, Svitlana Tyekucheva, Debora C. Bastos, Jeremy Tchaicha, Brian Lawney, Takuma Uo, Laura D'Anello, Alfredo Csibi, Radha Kalekar, Benjamin...

ARTIGO

Inglês

Agradecimentos: This work was supported by Department of Defense
(DoD) IMPACT Grant PC160357 (to M.L., S.M.D., and S.R.P.), DoD synergistic
Grant W81XWH1410405 (to M.L. and U.M.), NIH Grants R01-CA131945 and
P50 CA90381, and the Prostate Cancer Foundation (PCF) (M.L.). G.Z. is a
recipient of the...

A hallmark of prostate cancer progression is dysregulation of lipid metabolism via overexpression of fatty acid synthase (FASN), a key enzyme in de novo fatty acid synthesis. Metastatic castration-resistant prostate cancer (mCRPC) develops resistance to inhibitors of androgen receptor (AR) signaling...

Fechado

Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer

Giorgia Zadra, Caroline F. Ribeiro, Paolo Chetta, Yeung Ho, Stefano Cacciatore, Xueliang Gao, Sudeepa Syamala, Clyde Bango, Cornelia Photopoulos, Ying Huang, Svitlana Tyekucheva, Debora C. Bastos, Jeremy Tchaicha, Brian Lawney, Takuma Uo, Laura D'Anello, Alfredo Csibi, Radha Kalekar, Benjamin...


										

Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer

Giorgia Zadra, Caroline F. Ribeiro, Paolo Chetta, Yeung Ho, Stefano Cacciatore, Xueliang Gao, Sudeepa Syamala, Clyde Bango, Cornelia Photopoulos, Ying Huang, Svitlana Tyekucheva, Debora C. Bastos, Jeremy Tchaicha, Brian Lawney, Takuma Uo, Laura D'Anello, Alfredo Csibi, Radha Kalekar, Benjamin...

    Fontes

    Proceedings of the National Academy of Sciences of the United States of America

    Vol. 116, no. 2 (Jan., 2019), p. 631-640