Activation of BDNF/TrkB/Akt pathway is associated with aggressiveness and unfavorable survival in oral squamous cell carcinoma

Activation of BDNF/TrkB/Akt pathway is associated with aggressiveness and unfavorable survival in oral squamous cell carcinoma

Juliana Kern de Moraes, Vivian Petersen Wagner, Felipe Paiva Fonseca, Gleyson Kleber do Amaral-Silva, Caroline Brunetto de Farias, Emily Ferreira Salles Pilar, Auro Gregianin, Rafael Roesler, Pablo Agustin Vargas, Manoela Domingues Martins

ARTIGO

Inglês

Agradecimentos: Postgraduate Research Group of the Hospital de Clinicas de Porto Alegre; Brazilian Federal Agency for Support and Evaluation of Graduate Education; Sao Paulo State Research FoundationFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2016/21785-4]

To evaluate the expression of brain-derived neurotrophic factor (BDNF), its tyrosine kinase receptor B (TrkB), and two downstream targets of this pathway, Akt and ribosomal protein S6 (RPS6), in normal oral mucosa (NOM), oral leukoplakia (OL), and oral squamous cell carcinoma (OSCC) and correlate...

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP

Fechado

Activation of BDNF/TrkB/Akt pathway is associated with aggressiveness and unfavorable survival in oral squamous cell carcinoma

Juliana Kern de Moraes, Vivian Petersen Wagner, Felipe Paiva Fonseca, Gleyson Kleber do Amaral-Silva, Caroline Brunetto de Farias, Emily Ferreira Salles Pilar, Auro Gregianin, Rafael Roesler, Pablo Agustin Vargas, Manoela Domingues Martins


										

Activation of BDNF/TrkB/Akt pathway is associated with aggressiveness and unfavorable survival in oral squamous cell carcinoma

Juliana Kern de Moraes, Vivian Petersen Wagner, Felipe Paiva Fonseca, Gleyson Kleber do Amaral-Silva, Caroline Brunetto de Farias, Emily Ferreira Salles Pilar, Auro Gregianin, Rafael Roesler, Pablo Agustin Vargas, Manoela Domingues Martins

    Fontes

    Oral diseases

    Vol. 25, no. 8 (Nov., 2019), p. 1925-1936