Fatty acid synthase (FASN) is the key molecule for catalyzing fatty acid synthesis and have been associated with several malignant tumors. We analyzed the expression of FASN and Ki‐67, by immunohistochemistry on 29 carcinomas ex‐pleomorphic adenoma (CXPAs) and 25 pleomorphic adenomas (PAs). Ki‐67...

Fatty acid synthase (FASN) is the key molecule for catalyzing fatty acid synthesis and have been associated with several malignant tumors. We analyzed the expression of FASN and Ki‐67, by immunohistochemistry on 29 carcinomas ex‐pleomorphic adenoma (CXPAs) and 25 pleomorphic adenomas (PAs). Ki‐67 proliferation index and FASN expression were significantly higher in patients with CXPA than patients with PA (P < 0.001). We found intense immunoreactivity for FASN in the malignant component of CXPAs, and these malignant areas also had intense nuclear immunoreactivity for Ki‐67. The present results suggest that overexpression of FASN in CXPAs might be associated with malignant transformation of ductal epithelial cells and/or myoepithelial cells from PA. FASN associated with Ki‐67 may be useful diagnostic markers for CXPA

CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ

305967/2014-20

COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES

5881102

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP

2012/10781-7; 2015/07304-0

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