Agradecimentos: This work was supported by grants from Research Support Foundation of Minas Gerais - FAPEMIG, National Council for Scientific and Technological Development - CNPq, Coordination of Improvement of High Education Personnel (CAPES), National Postdoctoral Program/CAPES (PNPD/CAPES) and...

Agradecimentos: This work was supported by grants from Research Support Foundation of Minas Gerais - FAPEMIG, National Council for Scientific and Technological Development - CNPq, Coordination of Improvement of High Education Personnel (CAPES), National Postdoctoral Program/CAPES (PNPD/CAPES) and Procad/Casadinho

Abstract: To evaluate the association of single nucleotide polymorphisms (SNPs) in genes/loci consistently altered in nonsyndromic oral clefts in patients with oral and breast cancer in a Brazilian population. This case-control study evaluated the association of SNPs in IRF6 (rs642961), WNT3A...

Abstract: To evaluate the association of single nucleotide polymorphisms (SNPs) in genes/loci consistently altered in nonsyndromic oral clefts in patients with oral and breast cancer in a Brazilian population. This case-control study evaluated the association of SNPs in IRF6 (rs642961), WNT3A (rs708111), GSK3ß (rs9879992), 8q24 (rs987525) and WNT11 (rs1533767), representing regions consistently identified as of susceptibility for oral clefts, with oral cancer (oral squamous cell carcinoma) and breast cancer. Logistic regression analyses were used for confounding adjustments, and p values =0.01 were considered statistically significant (Bonferroni correction = 0.05/5 polymorphic markers). The minor G allele of rs9879992 in GSK3ß was associated with oral cancer risk (p = 0.02), whereas rs1533767 in WNT11 showed a protective effect against it (p = 0.04). Several SNP-SNP interactions containing GSK3ß rs9879992 were significantly associated with oral cancer after 1000 permutation test. To breast cancer, the A allele of rs987525 was associated with increase risk in early stage (p = 0.02) and SNP-SNP interactions involving the 5 SNPs were significantly observed, with the most significant interaction among rs708111, rs1533767, rs9879992 and rs642961 (p1000permutation<0.001). Our results reveal associations of SNPs consistently altered in oral cleft with oral and breast cancer risk, raising interesting possibilities to identify risk markers for those tumors

CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE MINAS GERAIS - FAPEMIG

COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES

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