Agradecimentos: The authors appreciate the financial support provided by the Research Funding Agency from São Paulo State (FAPESP), São Paulo, SP, Brazil (Grant 2013/ 19473-6 to Dr. Enilson Antonio Sallum). The authors Isabela Lima França-Grohmann and João Paulo Menck Sangiorgio are PhD students of...

Agradecimentos: The authors appreciate the financial support provided by the Research Funding Agency from São Paulo State (FAPESP), São Paulo, SP, Brazil (Grant 2013/ 19473-6 to Dr. Enilson Antonio Sallum). The authors Isabela Lima França-Grohmann and João Paulo Menck Sangiorgio are PhD students of Piracicaba Dental School/State University of Campinas; the author Manuela Rocha Bueno is an MS student of Piracicaba Dental School/State University of Campinas; the authors Renato Corrêa Viana Casarin and Karina Gonzáles Silvério are associate professors of Piracicaba Dental School/State University of Campinas; and the authors Francisco Humberto Nociti Jr., Márcio Zafallon Casati, and Enilson Antonio Sallum are full professors of Piracicaba Dental School/State University of Campinas. The authors would like to recognize Tabatha do Amaral Kalenski and Cristiano Soares (veterinarians) who were in charge of animal care during all phases of the study, and Mariana Fugolin who assisted in the histological processing. The authors report no conflicts of interest related to this study

Abstract: This study aimed to evaluate, histomorphometrically, the use of collagen matrix (CM) and/or enamel matrix derivative (EMD) for the treatment of dehiscence-type recession defects in minipigs.Eight healthy, male, young BR-1 minipigs, with no periodontal disease were treated. Bilateral...

Abstract: This study aimed to evaluate, histomorphometrically, the use of collagen matrix (CM) and/or enamel matrix derivative (EMD) for the treatment of dehiscence-type recession defects in minipigs.Eight healthy, male, young BR-1 minipigs, with no periodontal disease were treated. Bilateral dehiscence-type defects were surgically created on the buccal of the mandibular premolars (PI and PII). After 30 days, the defects were randomly assigned to four groups: coronally advanced flap (CAF); CAF + CM; CAF + EMD; and CAF + CM + EMD (split-mouth design). The evaluated parameters (mm): total defect length; new cementum (NC); new bone (NB); gingival margin position; total epithelium length; epithelium on the root; connective tissue adaptation; and soft tissue thickness (STT).The EMD-treated groups showed a superior length of NC [4.13 ± 1.22 (CAF + EMD); 3.95 ± 1.11 (CAF + CM + EMD); 2.94 ± 0.77 (CAF + CM); 2.72 ± 0.81 (CAF), P = 0.02] and NB [3.21 ± 0.68 (CAF + CM + EMD); 3.01 ± 0.56 (CAF + EMD); 2.15 ± 0.47 (CAF + CM); 2.29 ± 0.82 (CAF), P = 0.005]. The CAF and CAF + CM groups showed a superior epithelial length when compared to EMD-treated groups after 3 months. A superior STT was observed for CAF + CM + EMD group (1.5 ± 0.33) when compared with the other groups [1.09 ± 0.26 (CAF + EMD); 1.04 ± 0.34 (CAF + CM); and 1.14 ± 0.29 (CAF), P = 0.03].The results of the present study indicate that EMD application, irrespective of the combination with CM, may improve the periodontal regeneration of dehiscence-type defects in this animal model

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP

2013/19473-6

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