Liposomal butamben gel formulations : toxicity assays and topical anesthesia in an animal model
ARTIGO
Inglês
The aim of this study was to evaluate the in vitro cytotoxicity and the in vivo analgesic effect and local toxicity of the local anesthetic butamben (BTB) encapsulated in conventional or elastic liposomes incorporated in gel formulations. The results showed that both gel formulations of liposomal...
The aim of this study was to evaluate the in vitro cytotoxicity and the in vivo analgesic effect and local toxicity of the local anesthetic butamben (BTB) encapsulated in conventional or elastic liposomes incorporated in gel formulations. The results showed that both gel formulations of liposomal BTB reduced the cytotoxicity (p<0.001; one-way ANOVA/Tukey's test) and increased the topical analgesic effect (p<0.05; one-way ANOVA/Tukey's test) of butamben, compared to plain BTB gel. The gel formulations presented good rheological properties, and stability assays detected no differences in physicochemical stability up to 30 d after preparation. Moreover, histological assessment revealed no morphological changes in rat skin after application of any of the gel formulations tested
COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES
2611/09–0
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
2006/00121-9
fechado
Liposomal butamben gel formulations : toxicity assays and topical anesthesia in an animal model
Liposomal butamben gel formulations : toxicity assays and topical anesthesia in an animal model
Fontes
Journal of liposome research Vol. 27, no. 1 (Mar., 2017), p. 74-82 |