Antioxidant and vasodilator activity of Ugni molinae Turcz. (Murtilla) and its modulatory mechanism in hypotensive response
ARTIGO
Inglês
Hypertension is a systemic condition with high morbidity and mortality rates worldwide, which poses an increased risk for cardiovascular diseases. In this study, we demonstrated the antioxidant and vasodilator activity of Ugni molinae Turcz. (Murtilla) fruit, a berry native to Chile and proposed...
Hypertension is a systemic condition with high morbidity and mortality rates worldwide, which poses an increased risk for cardiovascular diseases. In this study, we demonstrated the antioxidant and vasodilator activity of Ugni molinae Turcz. (Murtilla) fruit, a berry native to Chile and proposed models to explain its modulatory mechanism in hypotensive response. Murtilla fruits were cultivated in a germplasm bank and submitted to chemical and biological analyses. The phenolic compounds gallic acid, Catechin, Quercetin-3-beta-D-glucoside, Myricetin, Quercetin, and Kaempferol were identified. Murtilla extract did not generate toxic effects on human endothelial cells and had significant antioxidant activity against ROS production, lipid peroxidation, and superoxide anion production. Furthermore, it showed dose-dependent vasodilator activity in aortic rings in the presence of endothelium, whose hypotensive mechanism is partially mediated by nitric oxide synthase/guanylate cyclase and large-conductance calcium-dependent potassium channels. Murtilla fruits might potentially have beneficial effects on the management of cardiovascular diseases
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
2014/50235-7
aberto
DOI: https://doi.org/10.1155/2016/6513416
Texto completo: https://www.hindawi.com/journals/omcl/2016/6513416/
Antioxidant and vasodilator activity of Ugni molinae Turcz. (Murtilla) and its modulatory mechanism in hypotensive response
Antioxidant and vasodilator activity of Ugni molinae Turcz. (Murtilla) and its modulatory mechanism in hypotensive response
Fontes
Oxidative medicine and cellular longevity Vol. 2016 (2016), n. art. 6513416 |